Setx - senataxin Gene

Also Known as AOA2; Als4; Sen1; SCAR1; mKIAA0625; A130090N03; A930037J23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 269254

Summary

Predicted to enable RNA binding activity; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Acts upstream of or within circadian rhythm and termination of RNA polymerase II transcription. Predicted to be located in several cellular components, including growth cone; intercellular bridge; and nuclear lumen. Predicted to be active in nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Orthologous to human SETX (senataxin). [provided by Alliance of Genome Resources, Apr 2022]

Setx Products (1)

mRNA Protein Name
NM_198033.2 NP_932150.2 probable helicase senataxin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22767893 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within circadian rhythm IMP
IMP: Inferred from mutant phenotype
22767893 MGI
acts upstream of or within termination of RNA polymerase II transcription IMP
IMP: Inferred from mutant phenotype
22767893 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable helicase senataxin

  • SEN1 homolog

  • amyotrophic lateral sclerosis 4 homolog

  • amyotrophic lateral sclerosis 4 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12752 SETX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22320 Setx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28842 Setx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Setx NCBI NCBI:23064