2. Gene
  3. SGSM3 - small G protein signaling modulator 3 Gene

SGSM3 - small G protein signaling modulator 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MAP; CIP85; RUSC3; RUTBC3; RABGAP5; RabGAP-5; rabGAPLP

Gene ID: 27352 | Gene type: protein coding

About SGSM3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:40,370,594-40,410,289 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 45 paralogues. Ubiquitous expression in stomach (RPKM 33.5), prostate (RPKM 23.3) and 25 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including Rap protein signal transduction; positive regulation of GTPase activity; and regulation of Rab protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SGSM3 Products(12)

mRNA Protein Name
NM_001301849.2 NP_001288778.1 small G protein signaling modulator 3 isoform 2
NM_001350039.2 NP_001336968.1 small G protein signaling modulator 3 isoform 3
NM_001350040.2 NP_001336969.1 small G protein signaling modulator 3 isoform 4
NM_001350041.2 NP_001336970.1 small G protein signaling modulator 3 isoform 5
NM_001350042.2 NP_001336971.1 small G protein signaling modulator 3 isoform 6
NM_001350043.2 NP_001336972.1 small G protein signaling modulator 3 isoform 7
NM_001350044.2 NP_001336973.1 small G protein signaling modulator 3 isoform 8
NM_001350045.2 NP_001336974.1 small G protein signaling modulator 3 isoform 8
NM_001350046.2 NP_001336975.1 small G protein signaling modulator 3 isoform 9
NM_001350047.2 NP_001336976.1 small G protein signaling modulator 3 isoform 10
NM_001350048.2 NP_001336977.1 small G protein signaling modulator 3 isoform 11
NM_015705.6 NP_056520.2 small G protein signaling modulator 3 isoform 1

SGSM3 Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (119 - 324)

SH3_1

SH3_1: SH3 domain (486 - 531)

RUN

RUN: RUN domain (563 - 716)

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  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

small G protein signaling modulator 3

RUN and SH3 containing 3

Related Diseases

Diseases Alias
Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12815 SGSM3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SGSM3 VGNC VGNC:108035
Canis familiaris SGSM3 VGNC VGNC:46106
Rattus norvegicus SGSM3 RGD RGD:735113
Mus musculus SGSM3 MGD MGI:1916329
Bos taurus SGSM3 VGNC VGNC:34552