SGSM3 - small G protein signaling modulator 3 Gene

Also Known as MAP; CIP85; RUSC3; RUTBC3; RABGAP5; RabGAP-5; rabGAPLP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27352

About SGSM3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:40,370,594-40,410,289 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 45 paralogues. Ubiquitous expression in stomach (RPKM 33.5), prostate (RPKM 23.3) and 25 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including Rap protein signal transduction; positive regulation of GTPase activity; and regulation of Rab protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

SGSM3 Products (12)

mRNA Protein Name
NM_001301849.2 NP_001288778.1 small G protein signaling modulator 3 isoform 2
NM_001350039.2 NP_001336968.1 small G protein signaling modulator 3 isoform 3
NM_001350040.2 NP_001336969.1 small G protein signaling modulator 3 isoform 4
NM_001350041.2 NP_001336970.1 small G protein signaling modulator 3 isoform 5
NM_001350042.2 NP_001336971.1 small G protein signaling modulator 3 isoform 6
NM_001350043.2 NP_001336972.1 small G protein signaling modulator 3 isoform 7
NM_001350044.2 NP_001336973.1 small G protein signaling modulator 3 isoform 8
NM_001350045.2 NP_001336974.1 small G protein signaling modulator 3 isoform 8
NM_001350046.2 NP_001336975.1 small G protein signaling modulator 3 isoform 9
NM_001350047.2 NP_001336976.1 small G protein signaling modulator 3 isoform 10
NM_001350048.2 NP_001336977.1 small G protein signaling modulator 3 isoform 11
NM_015705.6 NP_056520.2 small G protein signaling modulator 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
17562788 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17509819 GOA
enables small GTPase binding IDA
IDA: Inferred from direct assay
17509819 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
17562788 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in Rap protein signal transduction IEP
IEP: Inferred from expression pattern
17509819 GOA
involved in plasma membrane to endosome transport IMP
IMP: Inferred from mutant phenotype
17562788 GOA
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
17562788 GOA
involved in regulation of Rab protein signal transduction IEP
IEP: Inferred from expression pattern
17509819 GOA
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytosol IDA
IDA: Inferred from direct assay
17562788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGSM3 Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (119 - 324)

SH3_1

SH3_1: SH3 domain (486 - 531)

RUN

RUN: RUN domain (563 - 716)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

small G protein signaling modulator 3

  • RUN and SH3 containing 3

SGSM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SGSM3 Q96HU1 LEMD2 Homo sapiens Q8NC56
Anti Tag CoIP
33961781
Intra
SGSM3 Q96HU1 LEMD2 Homo sapiens Q8NC56
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Perianal Hematoma

  • External Thrombosed Haemorrhoids

  • Thrombosed External Hemorrhoids
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12815 SGSM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SGSM3 VGNC VGNC:108035
Canis familiaris SGSM3 VGNC VGNC:46106
Rattus norvegicus SGSM3 RGD RGD:735113
Mus musculus SGSM3 MGD MGI:1916329
Bos taurus SGSM3 VGNC VGNC:34552
Others SGSM3 NCBI