Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

Also Known as Trp7; TRPC7; Trrp7; LTRPC2; 9830168K16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 28240

Summary

Enables ligand-gated Calcium Channel activity and manganese ion transmembrane transporter activity. Involved in several processes, including calcium ion transmembrane import into cytosol; calcium-mediated signaling using intracellular calcium source; and cellular response to temperature stimulus. Acts upstream of or within manganese ion transport and response to hydroperoxide. Located in cytoplasmic vesicle membrane; lysosomal membrane; and plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Apr 2022]

Trpm2 Products (2)

mRNA Protein Name
NM_001411900.1 NP_001398829.1 transient receptor potential cation channel subfamily M member 2
NM_138301.2 NP_612174.2 transient receptor potential cation channel subfamily M member 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ligand-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
21753080 MGI
enables manganese ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
11804595 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
21753080 MGI
involved in cellular response to temperature stimulus IMP
IMP: Inferred from mutant phenotype
27562954 MGI
involved in dendritic cell chemotaxis IMP
IMP: Inferred from mutant phenotype
21753080 MGI
involved in dendritic cell differentiation IMP
IMP: Inferred from mutant phenotype
21753080 MGI
acts upstream of or within manganese ion transport IDA
IDA: Inferred from direct assay
11804595 MGI
involved in release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
21753080 MGI
involved in response to heat IMP
IMP: Inferred from mutant phenotype
27562954 MGI
acts upstream of or within response to hydroperoxide IDA
IDA: Inferred from direct assay
11804595 MGI
involved in temperature homeostasis IMP
IMP: Inferred from mutant phenotype
27562954 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
21753080 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
21753080 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11804595 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 2

  • LTrpC-2

  • long transient receptor potential channel 2

  • transient receptor potential channel 7

  • transient receptor protein 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149143 JNJ-28583113 Inhibitor 98.82% Unkown
HY-P5883 TAT-M2NX Inhibitor 99.55% Unkown
HY-141713 ZA10 Inhibitor / Unkown
HY-178393 TRPM2-IN-2 Inhibitor / Unkown
HY-181481 2'-Deoxyadenosine-5'-O-diphosphoribose sodium Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm2 NCBI NCBI:7226