FBXL22 - F-box and leucine rich repeat protein 22 Gene

Also Known as Fbl22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 283807

Summary

This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases.[provided by RefSeq, Sep 2010]
Broad expression in endometrium (RPKM 6.9), prostate (RPKM 3.6) and 21 other tissues.

FBXL22 Products (1)

mRNA Protein Name
NG_027784.2 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22972877 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
22972877 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
22972877 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXL22 Q6P050 SKP1 Homo sapiens P63208
Y2H
22972877
Intra
FBXL22 Q6P050 SKP1 Homo sapiens P63208
Anti Tag CoIP
22972877
Intra
FBXL22 Q6P050 SKP1 Homo sapiens P63208
Anti Tag CoIP
33961781
Intra
FBXL22 Q6P050 FLNC Homo sapiens Q14315
Y2H
22972877
Intra
FBXL22 Q6P050 FLNC Homo sapiens Q14315
Anti Tag CoIP
22972877
Intra
FBXL22 Q6P050 ACTN2 Homo sapiens P35609
Y2H
22972877
Intra
FBXL22 Q6P050 ACTN2 Homo sapiens P35609
Anti Tag CoIP
22972877
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04799 FBXO22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04783 FBXL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04789 FBXL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04790 FBXL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18815 Fbxl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20155 Fbxo22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25305 Fbxl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26659 Fbxo22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown