Capn2 - calpain 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29154

Summary

Enables calcium ion binding activity; cytoskeletal protein binding activity; and enzyme binding activity. Contributes to calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to interferon-beta; positive regulation of cell death; and positive regulation of myoblast fusion. Located in several cellular components, including external side of plasma membrane; focal adhesion; and neuronal cell body. Colocalizes with mitochondrial intermembrane space. Biomarker of hypertrophic cardiomyopathy and sciatic neuropathy. Orthologous to human CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Apr 2022]

Capn2 Products (1)

mRNA Protein Name
NM_017116.2 NP_058812.1 calpain-2 catalytic subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
14976200 RGD
contributes to calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
7982961 RGD
enables calcium-dependent cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
14976200 RGD
enables cytoskeletal protein binding IDA
IDA: Inferred from direct assay
17429681 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
20850499 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15476820 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
7982961 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to pain IDA
IDA: Inferred from direct assay
25150005 RGD
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
22711986 RGD
involved in cellular response to interferon-beta IEP
IEP: Inferred from expression pattern
23390485 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23390485 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
24271063 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21268078 RGD
involved in positive regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
7657725 RGD
involved in positive regulation of phosphatidylcholine biosynthetic process IMP
IMP: Inferred from mutant phenotype
9481489 RGD
involved in protein autoprocessing IDA
IDA: Inferred from direct assay
17182728 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
17402852 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
22711986 RGD
involved in regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
25150005 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
15101113 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
15979593 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17182728 RGD
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
12404510 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
22711986 RGD
located in dendrite IDA
IDA: Inferred from direct assay
22711986 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
9299163 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
24271063 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12404510 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calpain-2 catalytic subunit

  • CANP 2

  • M-calpain

  • calcium-activated neutral proteinase 2

  • calpain 2, (m/II) large subunit

  • calpain II

  • calpain M-type

  • calpain-2 large subunit

  • millimolar-calpain

Capn2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Capn2 Q07009 srp-6 Caenorhabditis elegans G5EFH4
Enzymatic Study
17889653
Intra
Capn2 Q07009 Cast Rattus norvegicus P27321
X-Ray Diffraction
19020623
Intra
Capn2 Q07009 Cast Rattus norvegicus P27321
X-Ray Diffraction
19020622
Intra
Capn2 Q07009 Cast Rattus norvegicus P27321
GMS
19020623
Intra
Capn2 Q07009 Cast Rattus norvegicus P27321
NMR
19020622
Intra
Capn2 Q07009 Cast Rattus norvegicus P27321
GMS
19020622
Intra
Capn2 Q07009 Cast Rattus norvegicus P27321
SPR
17543955
Intra
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
X-Ray Diffraction
19020622
Intra
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
GMS
19020623
Intra
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
GMS
19020622
Intra
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
X-Ray Diffraction
10601010
Intra
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
NMR
19020622
Intra
Capn2 Q07009 Capns1 Rattus norvegicus Q64537
X-Ray Diffraction
19020623
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01889 CAPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01896 CAPNS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18379 Capn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24859 Capn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capn2 NCBI NCBI:824