Arg2 - arginase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29215

Summary

Enables Arginase activity and nitric-oxide synthase binding activity. Involved in several processes, including arginine catabolic process to ornithine; cellular response to cytokine stimulus; and cellular response to lipid. Located in mitochondrion. Used to study hypertension. Biomarker of acute kidney failure; end stage renal disease; hypertension; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ARG2 (Arginase 2). [provided by Alliance of Genome Resources, Apr 2022]

Arg2 Products (1)

mRNA Protein Name
NM_019168.2 NP_062041.2 arginase-2, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arginase activity IDA
IDA: Inferred from direct assay
11829529 RGD
enables nitric-oxide synthase binding IPI
IPI: Inferred from physical interaction
16537391 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16537391 RGD
Biological Process GO Annotation Evidence References Source
involved in arginine catabolic process to ornithine IDA
IDA: Inferred from direct assay
15753084 RGD
involved in arginine metabolic process IMP
IMP: Inferred from mutant phenotype
16537391 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
11250887 RGD
involved in cellular response to interleukin-4 IEP
IEP: Inferred from expression pattern
14618299 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
11250887 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
11250887 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
18192591 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
16735458 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
10050048 RGD
involved in negative regulation of nitric-oxide synthase activity IMP
IMP: Inferred from mutant phenotype
16537391 RGD
involved in negative regulation of striated muscle contraction IMP
IMP: Inferred from mutant phenotype
16537391 RGD
involved in regulation of L-arginine import across plasma membrane IDA
IDA: Inferred from direct assay
11120661 RGD
involved in regulation of nitric oxide biosynthetic process IEP
IEP: Inferred from expression pattern
11829529 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
16168957 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
15458774 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
15735325 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
16570515 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15254879 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
20388547 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
14532164 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
20039818 RGD
involved in response to mercury ion IEP
IEP: Inferred from expression pattern
17874066 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
18348861 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
14624471 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
14624471 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15888029 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
16537391 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

arginase-2, mitochondrial

  • AII type II arginase

  • arginase II

  • arginase type II

  • kidney-type arginase

  • non-hepatic arginase

  • type II arginase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16254 Hydrocortamate hydrochloride Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112885 nor-NOHA / Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112885B nor-NOHA monoacetate 99.99% Unkown
HY-112885C nor-NOHA dihydrochloride 99.61% Unkown
HY-112885A nor-NOHA acetate 99.52% Unkown
HY-RS00908 ARG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P4750 Acetyl-(D-Arg2)-GRF (1-29) amide (human) Antagonist 99.67% Unkown
HY-P10555 (D-Arg2, Sar 4)-Dermorphin (1-4) Agonist / Unkown
HY-RS17404 Arg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23859 Arg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arg2 NCBI NCBI:384