PAK2 - p21 (RAC1) activated kinase 2 Gene

Also Known as PAK-2; gamma-PAK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29432

About PAK2

Primary_assembly 11: 68,707,969-68,768,816 forward strand.mRatBN7.2:CM026984.1

This gene has 2 transcripts (splice variants), 297 orthologues, 36 paralogues and is associated with 10 phenotypes. Biased expression in Spleen (RPKM 256.), Thymus (RPKM 211.9) and 9 other tissues.

Summary

Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and protein tyrosine kinase activator activity. Involved in cardiac muscle hypertrophy and cellular response to transforming growth factor beta stimulus. Located in secretory granule. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

PAK2 Products (2)

mRNA Protein Name
NM_053306.4 NP_445758.3 serine/threonine-protein kinase PAK 2
NM_001393703.1 NP_001380632.1 serine/threonine-protein kinase PAK 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle hypertrophy IEP
IEP: Inferred from expression pattern
22564263 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
15629889 RGD
Cellular Component GO Annotation Evidence References Source
located in secretory granule IDA
IDA: Inferred from direct assay
11943200 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK2 Protein Structure

PBD

PBD: pfam00786 (72 - 129)

STKc_PAK2

STKc_PAK2: cd06655 (228 - 523)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 524 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 2

  • p21 (CDKN1A)-activated kinase 2

  • p21 protein (Cdc42/Rac)-activated kinase 2

  • p21-activated kinase 2

  • serine/threonine-protein kinase PAK 2-like

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-19635 G-5555 Inhibitor 99.88% Unkown
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-120940 AZ13705339 Inhibitor 98.57% Unkown
HY-19635A G-5555 hydrochloride Inhibitor 98.26% Unkown
HY-171034 PQA-18 Inhibitor 99.62% Unkown
HY-131043 NVS-PAK1-C Inhibitor 99.2% Unkown
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-184447 RN193 Inhibitor / Unkown
HY-182357 PAK1-IN-3 Inhibitor / Unkown
HY-116917 G-9791 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens PAK2 NCBI NCBI:5062