Eef2 - eukaryotic translation elongation factor 2 Gene

Also Known as Ef-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29565

Summary

Enables several functions, including 5S rRNA binding activity; actin filament binding activity; and p53 binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; positive regulation of cytoplasmic translation; and response to ischemia. Located in cytosol; membrane raft; and polysomal ribosome. Part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in glaucoma and spinocerebellar ataxia type 26. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Eef2 Products (1)

mRNA Protein Name
NM_017245.2 NP_058941.1 elongation factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables 5S rRNA binding IDA
IDA: Inferred from direct assay
3801485 RGD
enables RNA binding IDA
IDA: Inferred from direct assay
11681712 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
7988728 RGD
enables p53 binding IPI
IPI: Inferred from physical interaction
12891704 RGD
enables ribosome binding IDA
IDA: Inferred from direct assay
2390990 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
19625250 RGD
involved in glial cell proliferation IEP
IEP: Inferred from expression pattern
7696190 RGD
involved in positive regulation of cytoplasmic translation IMP
IMP: Inferred from mutant phenotype
19625250 RGD
involved in positive regulation of translation IDA
IDA: Inferred from direct assay
2390990 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: Inferred from expression pattern
18188169 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16339744 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
12899944 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
12899944 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
15211596 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
15211596 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16817885 RGD
involved in skeletal muscle cell differentiation IEP
IEP: Inferred from expression pattern
16682826 RGD
involved in skeletal muscle contraction IEP
IEP: Inferred from expression pattern
19188248 RGD
involved in translation at postsynapse IDA
IDA: Inferred from direct assay
20427644 RGD
involved in translation at postsynapse IEP
IEP: Inferred from expression pattern
20427644 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12891704 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20427644 RGD
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
3801485 RGD
located in ribosome IDA
IDA: Inferred from direct assay
12891704 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

elongation factor 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-117684 Cabamiquine Inhibitor 99.61% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-110096 A-484954 Inhibitor 99.57% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-100576 NH125 Inhibitor 99.63% Unkown
HY-126396 Sordarin sodium Inhibitor 99.0% Unkown
HY-146324 PROTAC eEF2K degrader-1 Activator 98.64% Unkown
HY-117684A Cabamiquine succinate Inhibitor 99.80% Unkown
HY-120904 AMPK-IN-1 Activator 95.19% Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-123024 Cefatrizine / Unkown
HY-176149 Fluoxetine-Conjugated Platinum(IV) prodrug-1 / Unkown
HY-177720 eEF2K degrader-2 / Unkown
HY-181506 TYMJ-01 / Unkown
HY-184950 eEF2K ligand-1 Ligand / Unkown
HY-RS04180 EEF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04181 EEF2K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20013 Eef2k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20725 Eef2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26516 Eef2k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27237 Eef2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eef2 NCBI NCBI:1938