EEF2 - eukaryotic translation elongation factor 2 Gene

Also Known as EF2; EF-2; EEF-2; SCA26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1938

About EEF2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,976,056-3,985,463 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 918.2), thyroid (RPKM 609.1) and 25 other tissues.

Summary

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

EEF2 Products (1)

mRNA Protein Name
NM_001961.4 NP_001952.1 elongation factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
26593721 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19417104 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
23823123 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
23636399 GOA
enables translation elongation factor activity IDA
IDA: Inferred from direct assay
26593721 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
23184662 GOA
involved in translational elongation IDA
IDA: Inferred from direct assay
26593721 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25064856 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
18809582 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF2 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (18 - 299)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (410 - 484)

EFG_II

EFG_II: Elongation Factor G, domain II (503 - 565)

EFG_IV

EFG_IV: Elongation factor G, domain IV (621 - 737)

EFG_C

EFG_C: Elongation factor G C-terminus (739 - 827)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 858 a.a.
Protein Preferred Names Protein Names

elongation factor 2

  • epididymis secretory sperm binding protein

EEF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EEF2 P13639 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
EEF2 P13639 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
EEF2 P13639 HTT Homo sapiens P42858
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

EEF2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81272 Elongation factor 2 Antibody (YA962) WB, ICC/IF, ChIP Human
HY-P81272A Elongation factor 2 Antibody (YA963) WB, ICC/IF Human, Mouse, Monkey, Rat
HY-P81272AA Elongation factor 2 Antibody (YA963)(PBS only) WB, ICC/IF Human, Mouse, Monkey, Rat
HY-P81272B Elongation factor 2 Antibody (YA964) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81272BA Elongation factor 2 Antibody (YA964)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82836 Phospho-Elongation Factor 2 (Thr56/Thr58) Antibody (YA2581) WB Human
HY-P82836A Phospho-Elongation Factor 2 (Thr56/Thr58) Antibody (YA2581)(PBS only) WB Human
HY-P84086 Elongation factor 2 Antibody (YA3783) WB, IHC-P, ICC/IF, ELISA Human
HY-P84086A Elongation factor 2 Antibody (YA3783)(PBS only) WB, IHC-P, ICC/IF, ELISA Human
HY-P85428 Elongation factor 2 Antibody (YA5120) WB Human, Mouse, Rat
HY-P85535 Elongation factor 2 Antibody (YA5227) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 26

  • Spinocerebellar Ataxia Type 26

  • SCA26

  • Ataxia, Spinocerebellar, Type 26
Diphtheria

  • Corynebacterium Infections

  • Corynebacterium Infection

  • Diphtherial Infection

  • Infection Due To Corynebacterium Diphtheriae
Refractory Hairy Cell Leukemia
Refractory Hematologic Cancer

  • Refractory Hematologic Malignancy
Fusariosis

  • Fusarium Infection
Retinal Melanoma

  • Malignant Retinal Melanoma

  • Malignant Melanoma Of Retina
Cerebellar Ataxia Type 41

  • Sca41
Myopathy, Tubular Aggregate, 1

  • Tubular Aggregate Myopathy

  • Tam

  • Myopathy With Tubular Aggregates

  • TAM1

  • Myopathy, Tubular Aggregate

  • Tubular Aggregate Myopathy 1
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-117684 Cabamiquine Inhibitor 99.61% Phase 2
HY-117684A Cabamiquine succinate Inhibitor 99.80% Phase 2

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110096 A-484954 Inhibitor 99.57% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-100576 NH125 Inhibitor 99.63% Unkown
HY-126396 Sordarin sodium Inhibitor 99.0% Unkown
HY-146324 PROTAC eEF2K degrader-1 Activator 98.64% Unkown
HY-120904 AMPK-IN-1 Activator 95.19% Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-123024 Cefatrizine / Unkown
HY-176149 Fluoxetine-Conjugated Platinum(IV) prodrug-1 / Unkown
HY-177720 eEF2K degrader-2 / Unkown
HY-181506 TYMJ-01 / Unkown
HY-184950 eEF2K ligand-1 Ligand / Unkown
HY-RS04180 EEF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04181 EEF2K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20013 Eef2k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20725 Eef2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26516 Eef2k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27237 Eef2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EEF2 RGD RGD:61979
Canis familiaris EEF2 VGNC VGNC:40209
Mus musculus EEF2 MGD MGI:95288
Bos taurus EEF2 VGNC VGNC:28335
Felis catus EEF2 VGNC VGNC:78444
Macaca mulatta EEF2 VGNC VGNC:97763
Others EEF2 NCBI