Usp8 - ubiquitin specific peptidase 8 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 296121

Summary

Predicted to enable thiol-dependent Deubiquitinase. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in cytosol and dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with early endosome. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]

Usp8 Products (1)

mRNA Protein Name
NM_001106502.1 NP_001099972.1 ubiquitin carboxyl-terminal hydrolase 8

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
19527720 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
25662281 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
25505317 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
25505317 RGD
involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
25505317 RGD
Cellular Component GO Annotation Evidence References Source
located in early endosome IDA
IDA: Inferred from direct assay
25662281 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25505317 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25505317 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25505317 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 8

  • ubiquitin specific protease 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162312 LLK203 Inhibitor 98.58% Unkown
HY-151563A OTUB1/USP8-IN-1 TFA Inhibitor 99.56% Unkown
HY-149902 USP8-IN-3 Inhibitor 98.37% Unkown
HY-149901 USP8-IN-2 Inhibitor 99.91% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp8 NCBI NCBI:9101