ADAM10 - ADAM metallopeptidase domain 10 Gene

Also Known as MADM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29650

About ADAM10

Primary_assembly 8: 71,345,837-71,477,889 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 371 orthologues, 29 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 367.5), Thymus (RPKM 291.3) and 9 other tissues.

Summary

Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including dendritic spine; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of Alzheimer's disease; cardiomyopathy; cataract; status epilepticus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Apr 2022]

ADAM10 Products (1)

mRNA Protein Name
NM_019254.1 NP_062127.1 disintegrin and metalloproteinase domain-containing protein 10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metalloendopeptidase activity IDA
IDA: Inferred from direct assay
10423016 RGD
Biological Process GO Annotation Evidence References Source
involved in amyloid-beta formation IMP
IMP: Inferred from mutant phenotype
17301176 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
21503882 RGD
involved in regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
22328515 RGD
involved in response to antineoplastic agent IEP
IEP: Inferred from expression pattern
21503882 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
25053185 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21503882 RGD
located in dendrite IDA
IDA: Inferred from direct assay
25429624 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
17301176 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17301176 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
25429624 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
17301176 RGD
located in postsynapse IDA
IDA: Inferred from direct assay
22328515 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
17301176 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
26296617 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
10423016 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM10 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: cl03265 (45 - 155)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (220 - 459)

DISIN

DISIN: smart00050 (466 - 545)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 10

  • ADAM 10

  • RGD1566370

  • a disintegrin and metallopeptidase domain 10

  • a disintegrin and metalloprotease domain 10

  • kuzbanian protein homolog

  • mammalian disintegrin-metalloprotease

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10293 Aderbasib Inhibitor 99.44% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115670 GW280264X Inhibitor 99.30% Unkown
HY-16657 TAPI-1 Inhibitor 99.36% Unkown
HY-110397 KP-457 Inhibitor 98.88% Unkown
HY-120852 JG26 Inhibitor 98.14% Unkown
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.54% Unkown
HY-108675 PPNDS tetrasodium Inhibitor 96.39% Unkown
HY-P11540 CCKBR agonist-1 Agonist 98.48% Unkown
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 Substrate 99.33% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ADAM10 NCBI NCBI:102