2. Gene
  3. ADAM10 - ADAM metallopeptidase domain 10 Gene

ADAM10 - ADAM metallopeptidase domain 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as MADM

Gene ID: 29650 | Gene type: protein coding

About ADAM10

Primary_assembly 8: 71,345,837-71,477,889 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 371 orthologues, 29 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 367.5), Thymus (RPKM 291.3) and 9 other tissues.

Summary

Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including dendritic spine; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of Alzheimer's disease; cardiomyopathy; cataract; status epilepticus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Apr 2022]

ADAM10 Products(1)

mRNA Protein Name
NM_019254.1 NP_062127.1 disintegrin and metalloproteinase domain-containing protein 10 precursor

ADAM10 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: cl03265 (45 - 155)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (220 - 459)

DISIN

DISIN: smart00050 (466 - 545)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 10

ADAM 10

RGD1566370

a disintegrin and metallopeptidase domain 10

a disintegrin and metalloprotease domain 10

kuzbanian protein homolog

mammalian disintegrin-metalloprotease

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10293 Aderbasib Inhibitor 98.09% Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115670 GW280264X Inhibitor 98.28% Unkown
HY-110397 KP-457 Inhibitor 99.18% Unkown
HY-108675 PPNDS tetrasodium Inhibitor 96.39% Unkown
HY-120852 JG26 Inhibitor 98.01% Unkown
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.21% Unkown
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ADAM10 NCBI NCBI:102