Hip1r - huntingtin interacting protein 1 related Gene

Also Known as mKIAA0655

Species: Mus musculus

Gene Type: protein coding

Gene ID: 29816

Summary

Enables several functions, including SH3 domain binding activity; clathrin binding activity; and protein dimerization activity. Involved in several processes, including negative regulation of supramolecular fiber organization; positive regulation of clathrin coat assembly; and regulation of gastric acid secretion. Acts upstream of or within receptor-mediated endocytosis. Located in several cellular components, including apical plasma membrane; clathrin-coated pit; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; bone; central nervous system; genitourinary system; and sensory organ. Orthologous to human HIP1R (Huntingtin interacting protein 1 related). [provided by Alliance of Genome Resources, Apr 2022]

Hip1r Products (1)

mRNA	Protein	Name
NM_145070.3	NP_659507.3	huntingtin-interacting protein 1-related protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH3 domain binding	IDA IDA: Inferred from direct assay	17318189	MGI
enables actin binding	IDA IDA: Inferred from direct assay	10613908	MGI
enables actin filament binding	IDA IDA: Inferred from direct assay	11564758	MGI
enables clathrin adaptor activity	IDA IDA: Inferred from direct assay	11564758	MGI
enables clathrin binding	IDA IDA: Inferred from direct assay	11564758	MGI
enables clathrin light chain binding	IPI IPI: Inferred from physical interaction	15533940	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15090612	MGI
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	15533940	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	11564758	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in clathrin coat assembly	IDA IDA: Inferred from direct assay	11564758	MGI
involved in digestive system development	IMP IMP: Inferred from mutant phenotype	18535670	MGI
involved in membrane organization	IMP IMP: Inferred from mutant phenotype	18535670	MGI
involved in negative regulation of Arp2/3 complex-mediated actin nucleation	IDA IDA: Inferred from direct assay	17318189	MGI
involved in negative regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	17318189	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18535670	MGI
involved in positive regulation of clathrin coat assembly	IDA IDA: Inferred from direct assay	15533940	MGI
acts upstream of or within receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	10613908	MGI
involved in regulation of actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	14742709	MGI
involved in regulation of gastric acid secretion	IMP IMP: Inferred from mutant phenotype	18535670	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18535670	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	11564758	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	10613908	MGI
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	10613908	MGI
located in cytoskeleton	IDA IDA: Inferred from direct assay	10613908	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10613908	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
huntingtin-interacting protein 1-related protein	HIP1-related protein

Hip1r Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Hip1r	Q9JKY5	SH3KBP1	Homo sapiens	Q96B97	Anti Tag CoIP	15090612
Intra	Hip1r	Q9JKY5	Cttn	Mus musculus	Q60598	Pull Down	17318189
Cross	Hip1r	Q9JKY5	Egfr	Rattus norvegicus	G3V6K6	Anti Tag CoIP	30574069

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-179558	MS1-96	Degrader	/	Unkown
HY-RS06180	HIP1R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hip1r	NCBI	NCBI:9026