Rbx1 - ring-box 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 300084

Summary

Predicted to enable cullin family protein binding activity; ubiquitin protein Ligase binding activity; and ubiquitin-like protein Ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cellular protein metabolic process; and protein modification by small protein conjugation. Predicted to act upstream of or within protein K48-linked ubiquitination; protein catabolic process; and protein monoubiquitination. Part of VCB complex. Orthologous to human RBX1 (ring-box 1). [provided by Alliance of Genome Resources, Apr 2022]

Rbx1 Products (1)

mRNA Protein Name
NM_001034135.2 NP_001029307.1 E3 ubiquitin-protein ligase RBX1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10213691 RGD
Cellular Component GO Annotation Evidence References Source
part of VCB complex IDA
IDA: Inferred from direct assay
10213691 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RBX1

  • RING-box protein 1

  • ring-box 1, E3 ubiquitin protein ligase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14658 Thalidomide Inducer 99.98% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14571 E7820 Inhibitor 99.26% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115568 BETd-246 Inhibitor 98.34% Unkown
HY-RS11776 RBX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14658S Thalidomide-d4 Inducer 98.71% Unkown
HY-162240 SJH1-51B Degrader / Unkown
HY-182063 Z226407860 Inhibitor / Unkown
HY-RS18150 Rbx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24625 Rbx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rbx1 NCBI NCBI:9978