Lrp6 - LDL receptor related protein 6 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 312781

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including canonical Wnt signaling pathway; positive regulation of cytosolic calcium ion concentration; and response to peptide hormone. Located in neuronal cell body and synapse. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human LRP6 (LDL receptor related protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Lrp6 Products (2)

mRNA Protein Name
NM_001107892.1 NP_001101362.1 low-density lipoprotein receptor-related protein 6
NM_001401820.1 NP_001388749.1 low-density lipoprotein receptor-related protein 6 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18006602 RGD
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18006602 RGD
involved in chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
20404321 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
20404321 RGD
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18006602 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15962290 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
20404321 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-17439 Salinomycin sodium salt 99.81% Yes
HY-15597 Salinomycin 99.74% Yes
HY-122816 HLY78 98.44% Unkown
HY-D0961 Gallocyanine chloride Activator 92.00% Unkown
HY-70005 CPA inhibitor 99.78% Unkown
HY-170035 GlcCer (d18:1/18:0) Activator 99.93% Unkown
HY-100853 IWP-O1 Inhibitor 99.81% Unkown
HY-160709 Wnt/β-catenin-IN-2 Inhibitor 99.46% Unkown
HY-178335 SGC-CK1γ-1 Inhibitor 99.33% Unkown
HY-RS16293 Lrp6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176488 Y-99 Inhibitor / Unkown
HY-181160 JNK3/Wnt/β-catenin modulator-1 / Unkown
HY-181560 SLD1121 Agonist / Unkown
HY-181586 CK1γ-IN-1 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-184177 W2A-28 / Unkown
HY-E70390 C1s Enzyme Antagonist / Unkown
HY-E70661 CDK14/CycY Recombinant Human Active Protein Kinase / Unkown
HY-RS07801 LRP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-RS23672 Lrp6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991311 GSK3178022 Inhibitor / Unkown
HY-P992264 Anti-LRP6 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp6 NCBI NCBI:4040