LRP6 - LDL receptor related protein 6 Gene

Also Known as ADCAD2; STHAG7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4040

About LRP6

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:12,116,025-12,267,044 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 214 orthologues, 14 paralogues and is associated with 5 phenotypes. Ubiquitous expression in placenta (RPKM 10.1), ovary (RPKM 7.4) and 24 other tissues.

Summary

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many Cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]

LRP6 Products (13)

mRNA	Protein	Name
NM_001414244.1	NP_001401173.1	low-density lipoprotein receptor-related protein 6 isoform a precursor
NM_001414245.1	NP_001401174.1	low-density lipoprotein receptor-related protein 6 isoform b precursor
NM_001414246.1	NP_001401175.1	low-density lipoprotein receptor-related protein 6 isoform c precursor
NM_001414247.1	NP_001401176.1	low-density lipoprotein receptor-related protein 6 isoform d precursor
NM_001414248.1	NP_001401177.1	low-density lipoprotein receptor-related protein 6 isoform e precursor
NM_001414249.1	NP_001401178.1	low-density lipoprotein receptor-related protein 6 isoform f precursor
NM_001414250.1	NP_001401179.1	low-density lipoprotein receptor-related protein 6 isoform g precursor
NM_001414251.1	NP_001401180.1	low-density lipoprotein receptor-related protein 6 isoform h precursor
NM_001414252.1	NP_001401181.1	low-density lipoprotein receptor-related protein 6 isoform i
NM_001414253.1	NP_001401182.1	low-density lipoprotein receptor-related protein 6 isoform i
NM_001414254.1	NP_001401183.1	low-density lipoprotein receptor-related protein 6 isoform i
NM_001414255.1	NP_001401184.1	low-density lipoprotein receptor-related protein 6 isoform j precursor
NM_002336.3	NP_002327.2	low-density lipoprotein receptor-related protein 6 isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	11029007	GOA
enables coreceptor activity	IDA IDA: Inferred from direct assay	11029007	GOA
enables frizzled binding	IPI IPI: Inferred from physical interaction	11029007	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12897152	GOA
enables kinase inhibitor activity	IMP IMP: Inferred from mutant phenotype	16365045	GOA
enables low-density lipoprotein particle receptor activity	IDA IDA: Inferred from direct assay	16263759	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11029007	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12897152	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	14739301	GOA
NOT enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	18350154	GOA
enables toxin transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16564009	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	11357136	GOA
acts upstream of or within canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16263759	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	11448771	GOA
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	16805831	GOA
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11029007	GOA
involved in cellular response to cholesterol	IMP IMP: Inferred from mutant phenotype	16890161	GOA
involved in negative regulation of protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19107203	GOA
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15271658	GOA
involved in neural crest cell differentiation	IDA IDA: Inferred from direct assay	11029007	GOA
involved in neural crest formation	IDA IDA: Inferred from direct assay	11029007	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14739301	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18215320	GOA
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	15271658	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12857724	GOA
involved in protein localization to plasma membrane	IPI IPI: Inferred from physical interaction	22899650	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	16890161	GOA
part of Wnt signalosome	IDA IDA: Inferred from direct assay	22899650	GOA
part of Wnt-Frizzled-LRP5/6 complex	IDA IDA: Inferred from direct assay	20093360	GOA
part of Wnt-Frizzled-LRP5/6 complex	IPI IPI: Inferred from physical interaction	11029007	GOA
colocalizes with caveola	IDA IDA: Inferred from direct assay	16890161	GOA
located in cell surface	IDA IDA: Inferred from direct assay	12897152	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	16890161	GOA
colocalizes with early endosome	IDA IDA: Inferred from direct assay	16890161	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16263759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP6 Protein Structure

Ldl_recept_b

FXa_inhibition

Ldl_recept_b

FXa_inhibition

Ldl_recept_b

FXa_inhibition

Ldl_recept_b

Ldl_recept_a

0
300
600
900
1200
1500
1613 a.a.

Protein Preferred Names	Protein Names
low-density lipoprotein receptor-related protein 6	LRP-6

LRP6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LRP6	O75581	DAB2	Homo sapiens	P98082	Pull Down	22491013
Intra	LRP6	O75581	DAB2	Homo sapiens	P98082	Anti Tag CoIP	22491013
Intra	LRP6	O75581	DKK2	Homo sapiens	Q9UBU2	BLI	21944579
Cross	LRP6	O75581	Igfbp4	Mus musculus	P47879	Anti Tag CoIP	18528331
Cross	LRP6	O75581	Wnt1	Mus musculus	P04426	Pull Down	11448771
Cross	LRP6	O75581	Wnt1	Mus musculus	P04426	Pull Down	11029007
Intra	LRP6	O75581	CKLF	Homo sapiens	Q9UBR5	Y2H Prey Pooling	32296183
Intra	LRP6	O75581	CKLF	Homo sapiens	Q9UBR5	Validated Y2H	32296183
Intra	LRP6	O75581	CKLF	Homo sapiens	Q9UBR5	Y2H Array	32296183
Cross	LRP6	O75581	Wnt3a	Mus musculus	P27467	Anti Tag CoIP	12897152
Cross	LRP6	O75581	Wnt3a	Mus musculus	P27467	Anti Tag CoIP	18528331
Intra	LRP6	O75581	GSK3B	Homo sapiens	P49841	Pull Down	16365045
Intra	LRP6	O75581	GSK3B	Homo sapiens	P49841	Anti Tag CoIP	16890161
Intra	LRP6	O75581	LRRK2	Homo sapiens	Q5S007	Confocal	22899650
Intra	LRP6	O75581	SOST	Homo sapiens	Q9BQB4	X-Ray Diffraction	21944579
Intra	LRP6	O75581	SOST	Homo sapiens	Q9BQB4	BLI	21944579
Intra	LRP6	O75581	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	16890161
Intra	LRP6	O75581	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	16890161
Cross	LRP6	O75581	Fzd8	Mus musculus	Q61091	Pull Down	15908424
Cross	LRP6	O75581	Fzd8	Mus musculus	Q61091	Pull Down	11448771
Cross	LRP6	O75581	Fzd8	Mus musculus	Q61091	Pull Down	11029007
Intra	LRP6	O75581	WNT3A	Homo sapiens	P56704	BLI	21944579
Intra	LRP6	O75581	WNT3A	Homo sapiens	P56704	Anti Tag CoIP	22726442
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	GMS	21944579
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	Alpha-Screen	21984209
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	Pull Down	11448771
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	BLI	21944579
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	Light Scattering	21944579
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	DLS	21984209
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	X-Ray Diffraction	21984209
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	GMS	21984209
Intra	LRP6	O75581	DKK1	Homo sapiens	O94907	X-Ray Diffraction	21944579
Intra	LRP6	O75581	AMMECR1	Homo sapiens	Q9Y4X0	Anti Tag CoIP	21304492
Intra	LRP6	O75581	ANTXR1	Homo sapiens	Q9H6X2	Anti Tag CoIP	16564009
Cross	LRP6	O75581	Axin1	Rattus norvegicus	O70239	Anti Tag CoIP	16890161

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRP6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77990	LRP-6 Protein, Human (HEK293, mFc)	O75581 (A20-P630)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78837	LRP-6 Protein, Human (Biotinylated, HEK293, His-Avi)	O75581 (A20-P630)	≥ 90%, as determined by reducing SDS-PAGE.

LRP6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80212	LRP6 Antibody (YA708)	WB, IHC-P	Human
HY-P810758	Phospho-LRP6 (Ser1490) Antibody (YA10001)	WB	Human
HY-P86231	LRP6 Antibody (YA5923)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Coronary Artery Disease, Autosomal Dominant 2	Coronary Artery Disease, Autosomal Dominant, 2 ADCAD2 Artery, Coronary, Disease, Autosomal Dominant, Type 2
Tooth Agenesis, Selective, 7	STHAG7 Selective Tooth Agenesis 7
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Orofacial Cleft	Cleft, Orofacial
Orofacial Clefting Syndrome	Orofacial Clefting
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Anthrax Disease	Anthrax Ragpicker'S Disease Black Baine Malignant Edema Malignant Pustule Siberian Plague Wool Sorter'S Disease Gas Gangrene Cutaneous Anthrax Anthrax Infection Splenic Fever
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Craniodiaphyseal Dysplasia, Autosomal Dominant	CDD Autosomal Dominant Craniodiaphyseal Dysplasia Schaefer Stein Oshman Syndrome Craniodiaphyseal Dysplasia Autosomal Dominant
Ectodermal Dysplasia 13, Hair/Tooth Type	ECTD13 Ectodermal Dysplasia 13
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Osteopetrosis, Autosomal Dominant 1	OPTA1 Autosomal Dominant Osteopetrosis 1 Autosomal Dominant Osteopetrosis Type 1 Osteopetrosis Autosomal Dominant Type 1 Osteopetrosis, Autosomal Dominant, Type I Osteopetrosis, Autosomal Dominant, Type 1
Congenital Hydrocephalus	Hydrocephalus Hydrocephalus Adverse Event Hydrocephalus, Nonsyndromic, Autosomal Recessive 1 Hydrocephalus In Newborn Congenital Hydrocephaly
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Hyaline Fibromatosis Syndrome	Juvenile Hyaline Fibromatosis Inherited Systemic Hyalinosis Puretic Syndrome Infantile Systemic Hyalinosis HFS Hyalinosis, Systemic Systemic Hyalinosis Molluscum Fibrosum Murray Syndrome Murray-Puretic-Drescher Syndrome Ish Jhf Fibromatosis, Juvenile Hyaline Hyalinosis, Systemic Infantile Fibromatosis, Hyaline Syndrome Neurofibromatosis 1
Cenani-Lenz Syndactyly Syndrome	Syndactyly Type 7 Cenani Syndactylism Cenani-Lenz Syndactyly CLSS Syndactyly Cenani Lenz Type Cenani-Lenz Syndrome Syndactyly, Type Vii Cenani-Lenz Type Syndactyly Cenani Syndactyly Syndactyly Type Vii
Enterobiasis	Oxyuriasis Pinworm Infection Enterobius Vermicularis Infection Threadworm Infection Oxyuris Vermicularis Infection Enterobiosis Pinworm Pinworm Disease Seatworm Infection Enterobiasis Threadworm Pinworm Infestation Seatworm
Osteopathia Striata With Cranial Sclerosis	Hyperostosis Generalisata With Striations Robinow-Unger Syndrome OSCS Osteopathia Striata Cranial Sclerosis Osteopathia Striata-Cranial Sclerosis Syndrome Horan-Beighton Syndrome Os-Cs Osteopathia Striata - Cranial Sclerosis Voorhoeve Disease Osc
Anodontia	Complete Absence Of Teeth Developmental Absence Of Tooth Total Anodontia Of Permanent And Deciduous Teeth Absence Of Permanent Teeth Anodontia Of Permanent Dentition Agomphiasis Agomphosis Anodontism Complete Developmental Absence Of Teeth Congenital Absence Of Teeth Congenital Complete Absence Of Teeth Congenital Edentia Absence Of Teeth Absent Teeth Congenital Partial Absence Of Teeth Partial Absence Of Teeth Partial Anodontia
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Zygodactyly Syndactyly, Type I Sd1 Syndactyly, Type 1, With Or Without Craniosynostosis Symphalangism Non-Syndromic Syndactyly Symphalangy Webbing Of Digits Syndactyly, Type 1
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17439	Salinomycin sodium salt		99.81%	Yes
HY-15597	Salinomycin		99.74%	Yes
HY-122816	HLY78		98.44%	Unkown
HY-D0961	Gallocyanine chloride	Activator	92.00%	Unkown
HY-70005	CPA inhibitor		99.78%	Unkown
HY-170035	GlcCer (d18:1/18:0)	Activator	99.93%	Unkown
HY-N0836	Jervine		99.28%	Unkown
HY-100853	IWP-O1	Inhibitor	99.81%	Unkown
HY-160709	Wnt/β-catenin-IN-2	Inhibitor	99.46%	Unkown
HY-178335	SGC-CK1γ-1	Inhibitor	99.33%	Unkown
HY-RS16293	Lrp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-176488	Y-99	Inhibitor	/	Unkown
HY-181160	JNK3/Wnt/β-catenin modulator-1		/	Unkown
HY-181560	SLD1121	Agonist	/	Unkown
HY-181586	CK1γ-IN-1	Inhibitor	/	Unkown
HY-181930	TNIK-IN-10		/	Unkown
HY-184177	W2A-28		/	Unkown
HY-E70390	C1s Enzyme	Antagonist	/	Unkown
HY-E70661	CDK14/CycY Recombinant Human Active Protein Kinase		/	Unkown
HY-RS07801	LRP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0836A	Jervine hydriodide		/	Unkown
HY-RS23672	Lrp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991311	GSK3178022	Inhibitor	/	Unkown
HY-P992264	Anti-LRP6 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRP6	RGD	RGD:1304749
Mus musculus	LRP6	MGD	MGI:1298218
Bos taurus	LRP6	VGNC	VGNC:30993
Canis familiaris	LRP6	VGNC	VGNC:42778
Felis catus	LRP6	VGNC	VGNC:68090
Macaca mulatta	LRP6	VGNC	VGNC:74446
Others	LRP6	NCBI