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Axin1 - axin 1 Gene

Also Known as Axin; axin-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 79257

Axin1 Products (1)

mRNA	Protein	Name
NM_024405.2	NP_077381.1	axin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables armadillo repeat domain binding	IDA IDA: Inferred from direct assay	9482734	RGD
enables beta-catenin binding	IDA IDA: Inferred from direct assay	9482734	RGD
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	10330181	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10330181	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10330181	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10944533	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	10228155	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16890161	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	9482734	RGD
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	15228590	RGD
involved in positive regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	10228155	RGD
involved in response to quercetin	IEP IEP: Inferred from expression pattern	28032729	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16890161	RGD
part of beta-catenin destruction complex	IDA IDA: Inferred from direct assay	10228155	RGD
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11113207	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	16815997	RGD
is active in synapse	IDA IDA: Inferred from direct assay	15228590	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
axin-1	GSK-3beta interacting protein rAxin axis inhibition protein 1 rAxin

Axin1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Axin1	O70239	CAV1	Homo sapiens	Q03135	Anti Tag CoIP	16890161
Cross	Axin1	O70239	CAV1	Homo sapiens	Q03135	IF	16890161
Cross	Axin1	O70239	LRP6	Homo sapiens	O75581	IF	16890161
Cross	Axin1	O70239	DVL1	Homo sapiens	O14640	Anti Tag CoIP	11425858
Cross	Axin1	O70239	DVL1	Homo sapiens	O14640	Pull Down	10330181
Intra	Axin1	O70239	Axin1	Rattus norvegicus	O70239	Y2H	10330181
Intra	Axin1	O70239	Axin1	Rattus norvegicus	O70239	X-Ray Diffraction	17529994
Intra	Axin1	O70239	Axin1	Rattus norvegicus	O70239	Pull Down	10330181
Intra	Axin1	O70239	Axin1	Rattus norvegicus	O70239	Anti Tag CoIP	10330181
Cross	Axin1	O70239	DVL1	Homo sapiens	O14640	Pull Down	11113207
Cross	Axin1	O70239	LRP6	Homo sapiens	O75581	Anti Tag CoIP	16890161
Cross	Axin1	O70239	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	11425858
Cross	Axin1	O70239	CSNK1E	Homo sapiens	P49674	Protein Kinase Assay	11425858
Cross	Axin1	O70239	AMMECR1	Homo sapiens	Q9Y4X0	Anti Tag CoIP	21304492
Cross	Axin1	O70239	LRP6	Homo sapiens	O75581	Anti Tag CoIP	21304492

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-147245	Basroparib	Inhibitor	98.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173349	TDI-012804	Inhibitor	/	Unkown
HY-RS22402	Axin1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-107528	FRATtide	Inhibitor	/	Unkown
HY-141543	YW2065	Inhibitor	99.91%	Unkown
HY-RS01291	AXIN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Axin1	NCBI	NCBI:8312