MAP3K7 - mitogen activated protein kinase kinase kinase 7 Gene

Also Known as Tak1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 313121

About MAP3K7

Primary_assembly 5: 46,357,931-46,415,597 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 113.9), Thymus (RPKM 113.1) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; positive regulation of intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytosol; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K7 Products (1)

mRNA Protein Name
NM_001107920.2 NP_001101390.2 mitogen-activated protein kinase kinase kinase 7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
16183734 RGD
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
28821620 RGD
enables MAP kinase kinase kinase activity IDA
IDA: Inferred from direct assay
16183734 RGD
enables histone kinase activity IDA
IDA: Inferred from direct assay
16125722 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
35352799 RGD
enables protein serine/threonine kinase binding IDA
IDA: Inferred from direct assay
34733837 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
27956576 RGD
enables type II transforming growth factor beta receptor binding IPI
IPI: Inferred from physical interaction
16360132 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
30760025 RGD
Biological Process GO Annotation Evidence References Source
involved in MAPK cascade IDA
IDA: Inferred from direct assay
16183734 RGD
involved in cellular response to angiotensin IDA
IDA: Inferred from direct assay
20659889 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
32734729 RGD
involved in cellular response to transforming growth factor beta stimulus IDA
IDA: Inferred from direct assay
16125722 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
32581266 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
20659889 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26002466 RGD
involved in negative regulation of voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
26584289 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
16183734 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
35078016 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
17947700 RGD
involved in positive regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
35078016 RGD
involved in positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
32971071 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
35078016 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
35078016 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16125722 RGD
involved in response to angiotensin IEP
IEP: Inferred from expression pattern
30854566 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
22388934 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K7 Protein Structure

STKc_TAK1

STKc_TAK1: cd14058 (41 - 291)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 606 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 7

  • TGF-beta activated kinase 1

  • mitogen-activated protein kinase kinase kinase 7-like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-RS08062 MAP3K7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08063 Map3k7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08064 MAP3K7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08065 MAP3K7CL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MAP3K7 NCBI NCBI:6885