2. Gene
  3. MAP3K7 - mitogen activated protein kinase kinase kinase 7 Gene

MAP3K7 - mitogen activated protein kinase kinase kinase 7 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tak1

Gene ID: 313121 | Gene type: protein coding

About MAP3K7

Primary_assembly 5: 46,357,931-46,415,597 forward strand.mRatBN7.2:CM026978.1

This gene has 4 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 113.9), Thymus (RPKM 113.1) and 9 other tissues.

Summary

Enables ATP binding activity and MAP kinase kinase kinase activity. Involved in MAPK cascade; positive regulation of intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytosol; plasma membrane; and postsynaptic density. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia 2 and prostate Cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

MAP3K7 Products(1)

mRNA Protein Name
NM_001107920.2 NP_001101390.2 mitogen-activated protein kinase kinase kinase 7

MAP3K7 Protein Structure

STKc_TAK1

STKc_TAK1: cd14058 (41 - 291)

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  • 606 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 7

TGF-beta activated kinase 1

mitogen-activated protein kinase kinase kinase 7-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-RS08062 MAP3K7 Human Pre-designed siRNA Set A / Unkown
HY-RS08063 Map3k7 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08064 MAP3K7 Rat Pre-designed siRNA Set A / Unkown
HY-RS08065 MAP3K7CL Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MAP3K7 NCBI NCBI:6885