HLA-E - major histocompatibility complex, class I, E Gene

Also Known as QA1; HLA-6.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3133

About HLA-E

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,489,509-30,494,194 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 572 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 452.2), lung (RPKM 398.4) and 24 other tissues.

Summary

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of Other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-E Products (1)

mRNA Protein Name
NM_005516.6 NP_005507.3 HLA class I histocompatibility antigen, alpha chain E precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class I protein binding IDA
IDA: Inferred from direct assay
9754572 GOA
enables T cell receptor binding IDA
IDA: Inferred from direct assay
16474394 GOA
enables beta-2-microglobulin binding IDA
IDA: Inferred from direct assay
16474394 GOA
enables beta-2-microglobulin binding IMP
IMP: Inferred from mutant phenotype
12411439 GOA
enables natural killer cell lectin-like receptor binding IPI
IPI: Inferred from physical interaction
25631937 GOA
enables peptide antigen binding IDA
IDA: Inferred from direct assay
9427624 GOA
enables peptide antigen binding IMP
IMP: Inferred from mutant phenotype
12411439 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9427624 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
18448674 GOA
Biological Process GO Annotation Evidence References Source
involved in CD8-positive, alpha-beta T cell activation IDA
IDA: Inferred from direct assay
25631937 GOA
involved in adaptive immune response IDA
IDA: Inferred from direct assay
25631937 GOA
involved in antibacterial humoral response IDA
IDA: Inferred from direct assay
25631937 GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IDA
IDA: Inferred from direct assay
9754572 GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class Ib IDA
IDA: Inferred from direct assay
20195504 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
25631937 GOA
involved in natural killer cell tolerance induction IDA
IDA: Inferred from direct assay
9486650 GOA
involved in negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
20195504 GOA
involved in negative regulation of natural killer cell activation IDA
IDA: Inferred from direct assay
37264229 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9486650 GOA
involved in positive regulation of CD8-positive, alpha-beta T cell activation IDA
IDA: Inferred from direct assay
28676677 GOA
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
25631937 GOA
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
20195504 GOA
involved in positive regulation of TRAIL production IDA
IDA: Inferred from direct assay
25631937 GOA
involved in positive regulation of antibody-dependent cellular cytotoxicity IDA
IDA: Inferred from direct assay
30134159 GOA
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
25631937 GOA
involved in positive regulation of interleukin-13 production IDA
IDA: Inferred from direct assay
25631937 GOA
involved in positive regulation of interleukin-4 production IDA
IDA: Inferred from direct assay
25631937 GOA
involved in positive regulation of natural killer cell activation IDA
IDA: Inferred from direct assay
37264229 GOA
involved in positive regulation of natural killer cell cytokine production IDA
IDA: Inferred from direct assay
30134159 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
23335510 GOA
involved in positive regulation of natural killer cell mediated immunity IDA
IDA: Inferred from direct assay
9754572 GOA
involved in positive regulation of natural killer cell proliferation IDA
IDA: Inferred from direct assay
30134159 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: Inferred from direct assay
25631937 GOA
involved in protection from natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9754572 GOA
involved in regulation of natural killer cell mediated immunity IDA
IDA: Inferred from direct assay
18448674 GOA
Cellular Component GO Annotation Evidence References Source
part of MHC class I protein complex IDA
IDA: Inferred from direct assay
12411439 GOA
part of MHC class Ib protein complex IDA
IDA: Inferred from direct assay
9427624 GOA
located in cell surface IDA
IDA: Inferred from direct assay
9754572 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9427624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-E Protein Structure

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (22 - 200)

C1-set

C1-set: Immunoglobulin C1-set domain (216 - 292)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
Protein Preferred Names Protein Names

HLA class I histocompatibility antigen, alpha chain E

  • MHC class I antigen E

HLA-E Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HLA-E P13747 HLA-F Homo sapiens P30511
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HLA-E Proteins

Cat. No. Product Name Accession Purity
HY-P77758 HLA-E*01:03&B2M&Peptide(VMAPRTLVL) Monomer Protein, Human (HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77760 HLA-E*01:03&B2M&Peptide(VMAPRTLVL) Tetramer Protein, Human (HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥ 95%, as determined by Bis-Tris PAGE.
HY-P77761 HLA-E*01:03&B2M&Peptide(VMAPRTLVL) Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥ 95%, as determined by Bis-Tris PAGE.

HLA-E Antibodies

Cat. No. Product Name Application Reactivity
HY-P83701 HLA E Antibody (YA3437) WB, IP, FC Human

Related Diseases

Diseases Alias
Choriocarcinoma

  • Chorioepithelioma
Rabies

  • Lyssa

  • Hydrophobia

  • St Hubert Disease
Human Cytomegalovirus Infection

  • Cytomegalovirus Infection

  • Cytomegalovirus Infections
Ceftazidime Allergy

  • Fortaz Allergy

  • Tazicef Allergy
Nk Cell Deficiency
Parotid Gland Adenoid Cystic Carcinoma

  • Adenoid Cystic Carcinoma Of Parotid Gland
Bare Lymphocyte Syndrome, Type I

  • Hla Class I Deficiency

  • Mhc Class I Deficiency

  • Bls, Type I

  • Bare Lymphocyte Syndrome Type I

  • Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

  • Blsi

  • Mhc Class 1 Deficiency

  • Major Histocompatibility Complex Class 1 Deficiency

  • Bare Lymphocyte Syndrome 1

  • BLS1

  • Bls I

  • Bls Type I

  • Bl-1

  • Bare Lymphocyte Syndrome Type 1

  • Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

  • Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

  • Bls - [Bare Lymphocyte Syndrome] Nos
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991610 S-095029 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11340 VMAPRTLFL Ligand / Unkown
HY-RS06215 HLA-E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992377 HY-0102 / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-E RGD RGD:1595923