Foxp3 - forkhead box P3 Gene

Also Known as RGD1562112

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 317382

Summary

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; asthma; bronchiolitis obliterans; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3). [provided by Alliance of Genome Resources, Apr 2022]

Foxp3 Products (1)

mRNA Protein Name
NM_001108250.1 NP_001101720.1 forkhead box protein P3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in establishment of endothelial blood-brain barrier IEP
IEP: Inferred from expression pattern
31027862 RGD
involved in negative regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
17878294 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19998507 RGD
involved in response to rapamycin IEP
IEP: Inferred from expression pattern
24507682 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

forkhead box protein P3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13624A Epirubicin hydrochloride Inhibitor 99.62% Yes
HY-13624 Epirubicin Inhibitor 99.61% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-159692A AZD8701 sodium Inhibitor 96.61% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1684 Peptide P60 Inhibitor 98.39% Unkown
HY-124131 DS-437 Inhibitor 99.22% Unkown
HY-P1453A CMD178 TFA Inhibitor 99.71% Unkown
HY-159692 AZD8701 Inhibitor 96.61% Unkown
HY-162946 Alkyne-P60 Inhibitor 99.96% Unkown
HY-P1453 CMD178 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxp3 NCBI NCBI:50943