Hcn4 - hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Gene

Also Known as Hcn3; Bcng3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 330953

Summary

Enables intracellular cAMP-activated cation channel activity. Acts upstream of or within cation transport; in utero embryonic development; and regulation of heart contraction. Located in axon. Is expressed in eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 4). [provided by Alliance of Genome Resources, Apr 2022]

Hcn4 Products (1)

mRNA Protein Name
NM_001081192.3 NP_001074661.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables intracellularly cAMP-activated cation channel activity IMP
IMP: Inferred from mutant phenotype
14657344 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15564593 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
14657344 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
14657344 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
14657344 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
23172916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

  • brain cyclic nucleotide-gated channel 3

  • hyperpolarization-activated, cyclic nucleotide-gated K+ 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160505 RO-275 Inhibitor 99.95% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-108574 CP 339818 hydrochloride Inhibitor 99.61% Unkown
HY-119102 BPU-11 98.08% Unkown
HY-114540 CP-339818 Inhibitor / Unkown
HY-186057 HCN2-IN-5 Inhibitor / Unkown
HY-186058 HCN2-IN-6 Inhibitor / Unkown
HY-186061A HCN2 modulator-8 Inhibitor / Unkown
HY-186062 HCN-IN-1 / Unkown
HY-RS06049 HCN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19140 Hcn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20286 Hcn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26794 Hcn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcn4 NCBI NCBI:10021