Gpbar1 - G protein-coupled bile acid receptor 1 Gene

Also Known as Tgr5; M-BAR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 338443

About Gpbar1

Primary_assembly 9: 75,860,677-75,863,168 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 75 orthologues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 11.), Lung (RPKM 9.7) and 9 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of cholangiocyte proliferation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of receptor complex. Biomarker of non-alcoholic steatohepatitis and polycystic kidney disease. Orthologous to human GPBAR1 (G protein-coupled Bile Acid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gpbar1 Products (2)

mRNA Protein Name
NM_177936.2 NP_808797.1 G-protein coupled bile acid receptor 1
NM_177936.2 NP_808797.1 G-protein coupled bile acid receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
12524422 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
28543567 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
28543567 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: Inferred from mutant phenotype
28543567 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: Inferred from mutant phenotype
28543567 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpbar1 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (18 - 282)

7tm_GPCRs

7tm_GPCRs: cd14964 (18 - 39)

7tm_GPCRs

7tm_GPCRs: cd14964 (49 - 70)

7tm_GPCRs

7tm_GPCRs: cd14964 (84 - 106)

7tm_GPCRs

7tm_GPCRs: cd14964 (124 - 140)

7tm_GPCRs

7tm_GPCRs: cd14964 (160 - 183)

7tm_GPCRs

7tm_GPCRs: cd14964 (221 - 243)

7tm_GPCRs

7tm_GPCRs: cd14964 (257 - 282)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

G-protein coupled bile acid receptor 1

  • G protein-coupled receptor

  • membrane-type receptor for bile acids

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101273 BAR502 Agonist 99.53% Phase 1

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143712 Allolithocholic acid 99.69% Unkown
HY-101274 BAR501 Agonist 99.95% Unkown
HY-146453 TGR5 Receptor Agonist 3 Agonist 95.0% Unkown
HY-147086 CAY10789 99.84% Unkown
HY-RS05622 GPBAR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145234 GPBAR1-IN-3 / Unkown
HY-107612 GPBAR-A Agonist / Unkown
HY-143712R Allolithocholic acid (Standard) / Unkown
HY-143712S1 Allolithocholic Acid-d4 / Unkown
HY-168329 TGR5 agonist 7 Agonist / Unkown
HY-171949 5β-Cholestane-3α,7α,12α,25-tetrol Activator / Unkown
HY-173466 LT-188A Agonist / Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-RS05623 Gpbar1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05624 Gpbar1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101274A (3α,5β,6β,7α)-BAR501 98.0% Unkown
HY-165155 CysLT1 receptor antagonist-1 Antagonist / Unkown
HY-168784 LTD4 antagonist 2 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpbar1 NCBI NCBI:151306