MALRD1 - MAM and LDL receptor class A domain containing 1 Gene

Homo sapiens

Also known as DIET1; C10orf112; bA265G8.2

Gene ID: 340895 | Gene type: protein coding

About MALRD1

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:19,046,927-19,734,478 (from NCBI)

This gene has 6 transcripts (splice variants), 109 orthologues and 4 paralogues. Biased expression in small intestine (RPKM 12.3) and duodenum (RPKM 11.0).

Summary

This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine Phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]

MALRD1 Products(1)

mRNA	Protein	Name
NM_001142308.3	NP_001135780.2	MAM and LDL-receptor class A domain-containing protein 1 precursor

MALRD1 Protein Structure

MAM

Ldl_recept_a

MAM

Ldl_recept_a

MAM

Ldl_recept_a

MAM

Ldl_recept_a

MAM

Ldl_recept_a

0
300
600
900
1200
1473 a.a.

Protein Preferred Names

Protein Names

MAM and LDL-receptor class A domain-containing protein 1

MAM and LDL-receptor class A domain-containing protein C10orf112

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07994	MALRD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MALRD1	VGNC	VGNC:57041
Rattus norvegicus	MALRD1	RGD	RGD:2320868
Macaca mulatta	MALRD1	VGNC	VGNC:106069
Mus musculus	MALRD1	MGD	MGI:1928271

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