MALRD1 - MAM and LDL receptor class A domain containing 1 Gene

Also Known as DIET1; C10orf112; bA265G8.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 340895

About MALRD1

Cytogenetic location: 10p12.31 Genomic coordinates (GRCh38): 10:19,046,927-19,734,478 (from NCBI)

This gene has 6 transcripts (splice variants), 109 orthologues and 4 paralogues. Biased expression in small intestine (RPKM 12.3) and duodenum (RPKM 11.0).

Summary

This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine Phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the apoE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]

MALRD1 Products (1)

mRNA Protein Name
NM_001142308.3 NP_001135780.2 MAM and LDL-receptor class A domain-containing protein 1 precursor

MALRD1 Protein Structure

MAM

MAM: MAM domain, meprin/A5/mu (1 - 110)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (119 - 155)

MAM

MAM: MAM domain, meprin/A5/mu (161 - 318)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (345 - 381)

MAM

MAM: MAM domain, meprin/A5/mu (386 - 551)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (559 - 591)

MAM

MAM: MAM domain, meprin/A5/mu (603 - 759)

MAM

MAM: MAM domain, meprin/A5/mu (817 - 864)

MAM

MAM: MAM domain, meprin/A5/mu (906 - 975)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1054 - 1085)

MAM

MAM: MAM domain, meprin/A5/mu (1095 - 1256)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1268 - 1304)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1313 - 1347)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1351 - 1388)

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  • 1473 a.a.
Protein Preferred Names Protein Names

MAM and LDL-receptor class A domain-containing protein 1

  • MAM and LDL-receptor class A domain-containing protein C10orf112

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07994 MALRD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MALRD1 VGNC VGNC:57041
Rattus norvegicus MALRD1 RGD RGD:2320868
Macaca mulatta MALRD1 VGNC VGNC:106069
Mus musculus MALRD1 MGD MGI:1928271
Others MALRD1 NCBI