IFNGR2 - interferon gamma receptor 2 Gene

Also Known as AF-1; IFGR2; IMD28; IFNGT1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3460

About IFNGR2

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,402,882-33,437,516 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 133 orthologues, 11 paralogues and is associated with 4 phenotypes. Ubiquitous expression in placenta (RPKM 30.0), appendix (RPKM 25.4) and 25 other tissues.

Summary

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial Infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

IFNGR2 Products (2)

mRNA	Protein	Name
NM_001329128.2	NP_001316057.1	interferon gamma receptor 2 isoform 1 precursor
NM_005534.4	NP_005525.2	interferon gamma receptor 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables type II interferon receptor activity	IDA IDA: Inferred from direct assay	20015550	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in type III interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	20015550	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	20015550	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFNGR2 Protein Structure

Tissue_fac

Interfer-bind

0
100
200
300
337 a.a.

Protein Preferred Names	Protein Names
interferon gamma receptor 2	IFN-gamma receptor 2

IFNGR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IFNGR2	P38484	RTP2	Homo sapiens	Q5QGT7	Validated Y2H	32296183
Intra	IFNGR2	P38484	ZDHHC24	Homo sapiens	Q6UX98	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM199	Homo sapiens	Q8N511	Validated Y2H	32296183
Intra	IFNGR2	P38484	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	IFNGR2	P38484	ADIPOQ	Homo sapiens	Q15848	Validated Y2H	32296183
Intra	IFNGR2	P38484	ADIPOQ	Homo sapiens	Q15848	Y2H Array	32296183
Intra	IFNGR2	P38484	ERMP1	Homo sapiens	Q7Z2K6	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM254	Homo sapiens	Q8TBM7	Validated Y2H	32296183
Intra	IFNGR2	P38484	CLEC7A	Homo sapiens	Q9BXN2-6	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	IFNGR2	P38484	BRICD5	Homo sapiens	Q6PL45-2	Validated Y2H	32296183
Intra	IFNGR2	P38484	CLDN19	Homo sapiens	Q8N6F1-2	Validated Y2H	32296183
Intra	IFNGR2	P38484	SLC52A1	Homo sapiens	Q9NWF4	Validated Y2H	32296183
Intra	IFNGR2	P38484	CD302	Homo sapiens	Q8IX05	Validated Y2H	32296183
Intra	IFNGR2	P38484	TREX1	Homo sapiens	Q9NSU2-1	Validated Y2H	32296183
Intra	IFNGR2	P38484	BTNL8	Homo sapiens	Q6UX41-6	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	IFNGR2	P38484	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	IFNGR2	P38484	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	IFNGR2	P38484	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
Intra	IFNGR2	P38484	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	IFNGR2	P38484	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183
Intra	IFNGR2	P38484	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	32296183
Intra	IFNGR2	P38484	BNIP3	Homo sapiens	Q12983	Validated Y2H	32296183
Intra	IFNGR2	P38484	UNC50	Homo sapiens	Q53HI1	Validated Y2H	32296183
Intra	IFNGR2	P38484	INSIG2	Homo sapiens	Q9Y5U4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFNGR2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7367	IFN-gamma R2 Protein, Human (CHO)	P38484 (S28-Q247)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Immunodeficiency 28	IMD28 Ifngr2 Deficiency Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive Immunodeficiency 28, Mycobacteriosis Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency Msmd Due To Complete Ifngammar2 Deficiency Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency Immunodeficiency, Type 28, Mycobacteriosis
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Dominant Msmd Due To Partial Ifngammar2 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Mycobacterium Abscessus
Tuberculous Salpingitis
Axillary Adenitis	Axillary Lymphadenitis
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Lepromatous Leprosy	Leprosy, Lepromatous Type L Leprosy Leprosy Lepromatous
Aneurysm, Intracranial Berry, 12	ANIB12 Intracranial Berry Aneurysm 12
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Silo Filler'S Disease	Silo Filler Disease Silo-Fillers' Disease
Opportunistic Bacterial Infectious Disease
Nocardiosis	Nocardia Infection Nocardia Infections Nocardia Infectious Disease Lung Nocardiosis Nocardiasis Nocardiosis Nos
Macs Syndrome	Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis Mycobacterium Avium Complex Disease Rin2 Syndrome Mycobacterium Avium-Intracellulare Infection Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis Mycobacterium Avium Complex Mycobacterium Avium Infection Infection Due To Mycobacterium Intracellulare Mac Disease Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome Rin2 Deficiency Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome MACS Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome
Immunodeficiency 21	Monocytopenia And Mycobacterial Infection Syndrome Monomac Gata2 Deficiency Monocytopenia With Susceptibility To Infections Dcml IMD21 Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections Monocyte - B - Natural Killer - Dendritic Cell Deficiency Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia
Sarcoidosis 1	Sarcoidosis Boeck Sarcoid Besnier-Boeck-Schaumann Disease SS1 Sarcoidosis, Susceptibility To, 1 Lymphogranulomatosis Hodgkin Disease Boeck'S Disease Boeck'S Sarcoid Schaumann'S Disease Or Syndrome Hutchinson-Boeck Disease Or Syndrome
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06589	IFNGR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18006	Ifngr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24479	Ifngr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IFNGR2	RGD	RGD:1307532
Macaca mulatta	IFNGR2	VGNC	VGNC:73569
Felis catus	IFNGR2	VGNC	VGNC:67706
Bos taurus	IFNGR2	VGNC	VGNC:30059
Mus musculus	IFNGR2	MGD	MGI:107654
Others	IFNGR2	NCBI