CAVIN4 - caveolae associated protein 4 Gene

Also Known as MURC; cavin-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 347273

About CAVIN4

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:100,576,867-100,588,389 (from NCBI)

This gene has 1 transcript (splice variant), 273 orthologues and 3 paralogues. Biased expression in heart (RPKM 18.1), prostate (RPKM 5.6) and 2 other tissues.

Summary

This gene encodes a protein containing two coiled-coil regions. The encoded protein promotes Rho/ROCK (Rho-kinase) signaling in cardiac muscles cells, and may facilitate myofibrillar organization. [provided by RefSeq, Jun 2013]

CAVIN4 Products (1)

mRNA Protein Name
NM_001018116.2 NP_001018126.1 caveolae-associated protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24567387 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21642240 GOA
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
19525939 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26497963 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAVIN4 Protein Structure

PTRF_SDPR

PTRF_SDPR: PTRF/SDPR family (27 - 264)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

caveolae-associated protein 4

  • muscle related coiled-coil protein

CAVIN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAVIN4 Q5BKX8 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
CAVIN4 Q5BKX8 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lipodystrophy, Congenital Generalized, Type 4

  • Congenital Generalized Lipodystrophy Type 4

  • CGL4

  • Berardinelli-Seip Congenital Lipodystrophy, Type 4, With Muscular Dystrophy

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 4, With Muscular Dystrophy

  • Berardinelli-Seip Congenital Lipodystrophy Type 4 With Muscular Dystrophy

  • Generalized Congenital Lipodystrophy With Myopathy

  • Congenital Generalised Lipodystrophy Type 4

  • Generalised Congenital Lipodystrophy Type 4

  • Generalised Congenital Lipodystrophy With Myopathy

  • Generalized Congenital Lipodystrophy Type 4

  • Gcl4

  • Congenital Generalized Lipodystrophy 4

  • Berardinelli-Seip Congenital Lipodystrophy Type 4
Myopathy, Congenital, Bailey-Bloch

  • Native American Myopathy

  • Nam

  • MYPBB

  • Myopathy, Congenital, Baily-Bloch

  • Anti-Hmg-Coa Myopathy

  • Anti-Srp Myopathy

  • Autoimmune Necrotizing Myositis

  • Imnm

  • Immune Myopathy With Myocyte Necrosis

  • Immune-Mediated Necrotizing Myopathy

  • Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia

  • Necrotizing Autoimmune Myopathy

  • Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome

  • Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
Alzheimer Disease 8

  • Ad8

  • Alzheimer'S Disease 8

  • Alzheimer Disease, Familial, 8

  • Alzheimer Disease, Familial 8

  • Alzheimer'S Disease 8, Late Onset
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01991 CAVIN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CAVIN4 RGD RGD:1310395
Mus musculus CAVIN4 MGD MGI:1915266
Canis familiaris CAVIN4 VGNC VGNC:38756
Felis catus CAVIN4 VGNC VGNC:102905
Bos taurus CAVIN4 VGNC VGNC:26805
Others CAVIN4 NCBI