Rac1 - Rac family small GTPase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363875

Summary

Enables several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including Rac protein signal transduction; bone resorption; and regulation of cellular biosynthetic process. Located in several cellular components, including Golgi membrane; cytosol; and dendritic spine. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Rac1 Products (1)

mRNA Protein Name
NM_134366.1 NP_599193.1 ras-related C3 botulinum toxin substrate 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
20671235 RGD
enables GTP binding IDA
IDA: Inferred from direct assay
12672819 RGD
enables GTPase activity IDA
IDA: Inferred from direct assay
12672819 RGD
enables Rho GDP-dissociation inhibitor binding IPI
IPI: Inferred from physical interaction
22564631 RGD
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
22679019 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15608632 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20861382 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
16040606 RGD
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
10350213 RGD
involved in actin filament organization IMP
IMP: Inferred from mutant phenotype
12413953 RGD
involved in bone resorption IDA
IDA: Inferred from direct assay
10350213 RGD
involved in cellular response to mechanical stimulus IDA
IDA: Inferred from direct assay
12105187 RGD
involved in chemotaxis IMP
IMP: Inferred from mutant phenotype
11756405 RGD
involved in mast cell chemotaxis IMP
IMP: Inferred from mutant phenotype
12413953 RGD
involved in positive regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
9487126 RGD
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
15788770 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
23412604 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
12105187 RGD
involved in postsynaptic actin cytoskeleton organization EXP
EXP: Inferred from Experiment
25284783 RGD
involved in postsynaptic actin cytoskeleton organization IDA
IDA: Inferred from direct assay
25284783 RGD
involved in postsynaptic actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25284783 RGD
involved in regulation of nitric oxide biosynthetic process IGI
IGI: Inferred from genetic interaction
16055727 RGD
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
20696765 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
25284783 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25284783 RGD
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25284783 RGD
located in Golgi membrane IDA
IDA: Inferred from direct assay
15147909 RGD
located in cytosol IDA
IDA: Inferred from direct assay
20696765 RGD
located in membrane IDA
IDA: Inferred from direct assay
20696765 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related C3 botulinum toxin substrate 1

  • p21-Rac1

  • ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)

  • rho family, small GTP binding protein Rac1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112842 MBQ-167 Inhibitor 99.85% Phase 1

Pre-clinical Phase

Bioactive Molecules (94)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10071 Y-27632 99.91% Unkown
HY-18723 Yoda 1 99.97% Unkown
HY-15723A NSC 23766 trihydrochloride 99.41% Unkown
HY-12755 ML141 99.96% Unkown
HY-12646 Rhosin hydrochloride 99.94% Unkown
HY-16659 EHT 1864 Inhibitor 99.85% Unkown
HY-12810 EHop-016 Inhibitor 99.38% Unkown
HY-125792 Nexinhib20 Inhibitor 99.86% Unkown
HY-12646A Rhosin 98.74% Unkown
HY-100047 Nα,Nα-Bis(carboxymethyl)-L-lysine 98.80% Unkown
HY-124306 ML-099 Activator 99.75% Unkown
HY-110100 CPYPP Inhibitor 99.80% Unkown
HY-104064 1A-116 99.72% Unkown
HY-115376 Z62954982 Inhibitor 99.38% Unkown
HY-N0710 alpha-Cyperone 99.68% Unkown
HY-U00145 Digeranyl bisphosphonate Inhibitor 99.07% Unkown
HY-107501 (Rac)-1-Oleoyl lysophosphatidic acid sodium 98.0% Unkown
HY-113849 MLS-573151 Inhibitor 99.66% Unkown
HY-118208 ML-097 Inhibitor 99.90% Unkown
HY-136383 AZA1 98.17% Unkown
HY-111355 Cholesterol sulfate 99.71% Unkown
HY-119576 Phox-I2 Inhibitor 99.46% Unkown
HY-B0580B (R)-Ketorolac Inhibitor 99.65% Unkown
HY-106381 Aurothiomalate sodium Inhibitor 98.0% Unkown
HY-102078 ZINC69391 99.12% Unkown
HY-15031 l-Naproxen Inhibitor 99.63% Unkown
HY-175341 Rac1-IN-5 Inhibitor 99.84% Unkown
HY-112307A (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium 99.97% Unkown
HY-133146 DJ001 Inhibitor 99.92% Unkown
HY-158304 Rac1-IN-4 Inhibitor 98.61% Unkown
HY-106381A Aurothiomalate tetramer sodium Inhibitor 98.0% Unkown
HY-120213 YH-306 98.34% Unkown
HY-143699S (Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5 98.51% Unkown
HY-50733A CX-5011 99.48% Unkown
HY-P10038A mP6 TFA Inhibitor 98.48% Unkown
HY-121667 Scaff10-8 Inhibitor 99.11% Unkown
HY-131598C 6-Thio-GTP tetrasodium Inhibitor 99.7% Unkown
HY-156668 Rac1-IN-3 Inhibitor 98.94% Unkown
HY-P1382A Rac1 Inhibitor W56 TFA Inhibitor 99.92% Unkown
HY-10071A Y-27632 hydrochloride hydrate 99.65% Unkown
HY-RS11591 RAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W127391 1,2-Dilaurin 98.0% Unkown
HY-152095 PPI-GIT1/β-Pix PPI-IN-1 Inhibitor 99.01% Unkown
HY-180801 E8431 97.34% Unkown
HY-W013060 (Rac)-1,2-Dilinoleoyl-3-palmitoyl-glycerol 99.0% Unkown
HY-W127550 1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium / Unkown
HY-50733 CX-5011 free base / Unkown
HY-115507 NMac1 / Unkown
HY-109541S6 (Rac)-Colfosceril miristate-d72 / Unkown
HY-120229 GGTI-2147 Inhibitor / Unkown
HY-137862A (Rac)-1-Oleoyl lysophosphatidic acid Control / Unkown
HY-146841S1 (Rac)-Lysophosphatidylcholine C19:0-d5 / Unkown
HY-147076 20:4 PG sodium / Unkown
HY-170458 18:0-18:2 PG sodium / Unkown
HY-172917 Rho GTPase inhibitor 1 Inhibitor / Unkown
HY-180371 NF-115 Inducer / Unkown
HY-183246 Rac/Cdc42-IN-1 Inhibitor / Unkown
HY-184184 Axl ligand-1 Ligand / Unkown
HY-E70632 PIP5K1B Recombinant Human Active Lipid Kinase / Unkown
HY-N8960A (Rac)-1-Hydroxybisabola-2,10-dien-4-one / Unkown
HY-P10038 mP6 Inhibitor / Unkown
HY-P10107 TAT-PAK18 R192A Control / Unkown
HY-P11092 TLQP-62 (mouse,rat) / Unkown
HY-P1382 Rac1 Inhibitor W56 Inhibitor / Unkown
HY-P1383A Rac1 Inhibitor F56, control peptide TFA Inhibitor / Unkown
HY-RS12018 RNASE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010270A Aurothiomalate disodium Inhibitor / Unkown
HY-W127356 (Rac)-1,2-Distearoyl-3-chloropropanediol-d5 / Unkown
HY-W127363 (Rac)-1,2-Dihexadecylglycerol / Unkown
HY-W127415 (Rac)-1-Stearoyl-3-chloropropanediol / Unkown
HY-W127415S (Rac)-1-Stearoyl-3-chloropropanediol-d5 / Unkown
HY-W127415S1 (Rac)-1-Stearoyl-3-chloropropanediol-d5-1 / Unkown
HY-W127570 rac-1,2-Distearoyl-3-chloropropanediol / Unkown
HY-W587715S (Rac)-1,2-Dioleoyl-3-chloropropanediol-d5 / Unkown
HY-W653931 rac 1,2-Bis-palmitoyl-3-chloropropanediol-13C3 / Unkown
HY-W749785 rac-1-Lauroyl-2-decanoyl-3-chloropropanediol-d5 / Unkown
HY-W766801 1-Linoleoyl-3-chloropropanediol-d5 / Unkown
HY-W766802 rac-1-Linoleoyl-2-linolenoyl-3-chloropropanediol-d5 / Unkown
HY-W767222 rac-1-Linoleoyl-2-chloropropanediol-d5 / Unkown
HY-W767223 rac 1-Palmitoyl-2-chloropropanediol-d5 / Unkown
HY-W770200 rac 1-Oleoyl-2,3-isopropylidieneglycerol-d5 / Unkown
HY-W777103 (Rac)-1-Oleoyl-3-linoleoyl-glycerol / Unkown
HY-W777682 (Rac)-1-Linoleoyl-2,3-isopropylidene-glycerol / Unkown
HY-W777871 rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5 / Unkown
HY-134243 6-T-GDP Inhibitor / Unkown
HY-181864 Rac1-IN-6 Inhibitor / Unkown
HY-RS16742 Rac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23179 Rac1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W702728 rac 1-Palmitoyl-2-chloropropanediol / Unkown
HY-W749756 rac-1,2-Distearoyl-3-chloropropanediol-13C3 / Unkown
HY-W766807 rac-1,2-Dilinoleoyl-3-chloropropanediol-d5 / Unkown
HY-W766831 rac 1-oleoyl-2-linoleoyl-3-chloropropanediol-d5 / Unkown
HY-W777865 1-Linoleoyl-3-chloropropanediol / Unkown
HY-W777866 (Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rac1 NCBI NCBI:5879