Axl ligand-1
Axl ligand-1 is a highly selective ligand for AXL kinase, exhibiting higher selectivity for AXL over 72 human kinases. Axl ligand-1 serves as a Ligand for Target Protein for PROTAC, which is applied to develop PROTAC degraders with anti-tumor activity, such as PROTAC Axl Degrader 1 (HY-144624). Axl ligand-1 is applicable to breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 3033401-32-7
- Formula: C19H18N8
- Molecular Weight:358.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Axl |
Axl ligand-1 serves as a target protein ligand for PROTAC Axl Degrader 1 (HY-144624). PROTAC Axl Degrader 1 is a potent and selective PROTAC degrader of Axl with an IC50 of 0.92 μM. PROTAC Axl Degrader 1 exhibits antiproliferative and antimigratory activities in vitro. PROTAC Axl Degrader 1 induces megakaryocytic cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033401-32-7
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Molecular Weight 358.40
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Formula C19H18N8
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SMILES
NC1=NC(NC2=CC=C(C=C2)CN)=NN1C3=CC=C(N=N3)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Axl ligand-1 Related Classifications
HY-184184 Related Classifications
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