RAC1 - Rac family small GTPase 1 Gene

Also Known as MIG5; MRD48; Rac-1; TC-25; p21-Rac1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5879

About RAC1

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:6,374,527-6,403,967 (from NCBI)

This gene has 9 transcripts (splice variants), 278 orthologues, 22 paralogues and is associated with 65 phenotypes. Ubiquitous expression in esophagus (RPKM 113.8), brain (RPKM 110.4) and 25 other tissues.

Summary

The protein encoded by this gene is a GTPase which belongs to the Ras superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

RAC1 Products (2)

mRNA	Protein	Name
NM_006908.5	NP_008839.2	ras-related C3 botulinum toxin substrate 1 isoform Rac1
NM_018890.4	NP_061485.1	ras-related C3 botulinum toxin substrate 1 isoform Rac1b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	12551911	GOA
enables GTP binding	IMP IMP: Inferred from mutant phenotype	19625648	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	19787194	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7673236	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8625410	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	21107423	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	12612085	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	19890013	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	23512198	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in cell motility	IDA IDA: Inferred from direct assay	19403692	GOA
involved in hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25198505	GOA
involved in lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	9312003	GOA
involved in localization within membrane	IMP IMP: Inferred from mutant phenotype	16636067	GOA
involved in negative regulation of fibroblast migration	IDA IDA: Inferred from direct assay	19126672	GOA
involved in negative regulation of interleukin-23 production	IDA IDA: Inferred from direct assay	16982892	GOA
involved in positive regulation of cell-substrate adhesion	IGI IGI: Inferred from genetic interaction	20926685	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18558630	GOA
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	23129259	GOA
acts upstream of or within positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	15467718	GOA
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	8625410	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	25198505	GOA
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	19625648	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23633677	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	23129259	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	8625410	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IDA IDA: Inferred from direct assay	23129259	GOA
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19934221	GOA
involved in regulation of cell size	IGI IGI: Inferred from genetic interaction	22467863	GOA
involved in regulation of cell size	IMP IMP: Inferred from mutant phenotype	22467863	GOA
involved in regulation of lamellipodium assembly	IGI IGI: Inferred from genetic interaction	8625410	GOA
involved in regulation of respiratory burst	IDA IDA: Inferred from direct assay	16636067	GOA
involved in regulation of stress fiber assembly	IGI IGI: Inferred from genetic interaction	8625410	GOA
involved in ruffle assembly	IMP IMP: Inferred from mutant phenotype	10036235	GOA
acts upstream of or within ruffle organization	IDA IDA: Inferred from direct assay	15467718	GOA
involved in small GTPase-mediated signal transduction	IMP IMP: Inferred from mutant phenotype	26934001	GOA
involved in sphingosine-1-phosphate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18558630	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19625648	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	19625648	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	19126672	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19625648	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15800193	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15800193	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	19126672	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12551911	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10036235	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	15800193	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	15800193	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	10036235	GOA
located in ruffle membrane	IDA IDA: Inferred from direct assay	20875796	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12915445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAC1 Protein Structure

Ras

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
ras-related C3 botulinum toxin substrate 1	cell migration-inducing gene 5 protein

RAC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAC1	P63000	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	RAC1	P63000	PAK2	Homo sapiens	Q13177	Y2H Pooling	20936779
Intra	RAC1	P63000	SET	Homo sapiens	Q01105	Pull Down	23195690
Intra	RAC1	P63000	SET	Homo sapiens	Q01105	Pull Down	17245428
Intra	RAC1	P63000	VPS29	Homo sapiens	Q9UBQ0-2	Y2H Array	32814053
Intra	RAC1	P63000	VPS29	Homo sapiens	Q9UBQ0-2	Y2H Pooling	32814053
Intra	RAC1	P63000	VPS29	Homo sapiens	Q9UBQ0-2	Validated Y2H	32814053
Intra	RAC1	P63000	HDAC7	Homo sapiens	Q8WUI4-6	Y2H Prey Pooling	32296183
Intra	RAC1	P63000	HDAC7	Homo sapiens	Q8WUI4-6	Validated Y2H	32296183
Intra	RAC1	P63000	HDAC7	Homo sapiens	Q8WUI4-6	MAPPIT	32296183
Intra	RAC1	P63000	HDAC7	Homo sapiens	Q8WUI4-6	Y2H Array	32296183
Intra	RAC1	P63000	PAK1	Homo sapiens	Q13153	Pull Down	19732720
Intra	RAC1	P63000	PAK1	Homo sapiens	Q13153	Pull Down	15688026
Intra	RAC1	P63000	PAK1	Homo sapiens	Q13153	Pull Down	22117219
Intra	RAC1	P63000	PAK1	Homo sapiens	Q13153	Pull Down	11950930
Intra	RAC1	P63000	PAK1	Homo sapiens	Q13153	Pull Down	19596003
Intra	RAC1	P63000	PAK1	Homo sapiens	Q13153	Y2H Pooling	20936779
Intra	RAC1	P63000	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	RAC1	P63000	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	RAC1	P63000	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	RAC1	P63000	SYK	Homo sapiens	P43405-2	Validated Y2H	32814053
Intra	RAC1	P63000	SYK	Homo sapiens	P43405-2	Y2H Pooling	32814053
Intra	RAC1	P63000	SYK	Homo sapiens	P43405-2	Y2H Array	32814053
Intra	RAC1	P63000	ARHGAP45	Homo sapiens	Q92619	Pull Down	24086303
Intra	RAC1	P63000	PRKCI	Homo sapiens	P41743	Y2H	11260256
Intra	RAC1	P63000	PRKCI	Homo sapiens	P41743	CoIP	11260256
Intra	RAC1	P63000	PARD6B	Homo sapiens	Q9BYG5	CoIP	11260256
Intra	RAC1	P63000	PARD6B	Homo sapiens	Q9BYG5	Y2H	11260256
Intra	RAC1	P63000	PARD6B	Homo sapiens	Q9BYG5	Pull Down	11260256
Intra	RAC1	P63000	PARD6G	Homo sapiens	Q9BYG4	Y2H	11260256
Intra	RAC1	P63000	PARD6G	Homo sapiens	Q9BYG4	Pull Down	11260256
Intra	RAC1	P63000	IQGAP1	Homo sapiens	P46940	Anti Bait CoIP	28007913
Intra	RAC1	P63000	IQGAP1	Homo sapiens	P46940	Anti Tag CoIP	35271311
Intra	RAC1	P63000	IQGAP1	Homo sapiens	P46940	Pull Down	28007913
Intra	RAC1	P63000	IQGAP1	Homo sapiens	P46940	Anti Tag CoIP	31980649
Intra	RAC1	P63000	IQGAP1	Homo sapiens	P46940	IF	18809683
Intra	RAC1	P63000	IQGAP1	Homo sapiens	P46940	TAP	27173435
Intra	RAC1	P63000	SH3RF1	Homo sapiens	Q7Z6J0	Solid Phase Assay	20696164
Intra	RAC1	P63000	FLNB	Homo sapiens	O75369	Pull Down	19270716
Intra	RAC1	P63000	PFDN2	Homo sapiens	Q9UHV9	Validated Y2H	32814053
Intra	RAC1	P63000	PFDN2	Homo sapiens	Q9UHV9	Y2H Array	32814053
Intra	RAC1	P63000	PFDN2	Homo sapiens	Q9UHV9	Y2H Pooling	32814053
Intra	RAC1	P63000	AATF	Homo sapiens	Q9NY61	Validated Y2H	32814053
Intra	RAC1	P63000	AATF	Homo sapiens	Q9NY61	Y2H Array	32814053
Intra	RAC1	P63000	AATF	Homo sapiens	Q9NY61	Y2H Pooling	32814053
Intra	RAC1	P63000	CDC23	Homo sapiens	Q9UJX2	Y2H Prey Pooling	25416956
Intra	RAC1	P63000	DOCK1	Homo sapiens	Q14185	Pull Down	15723800
Intra	RAC1	P63000	DOCK1	Homo sapiens	Q14185	Pull Down	15247908
Intra	RAC1	P63000	DOCK2	Homo sapiens	Q92608	Pull Down	15723800
Intra	RAC1	P63000	DOCK2	Homo sapiens	Q92608	Pull Down	12134158
Intra	RAC1	P63000	S100B	Homo sapiens	P04271	Validated Y2H	32814053
Intra	RAC1	P63000	S100B	Homo sapiens	P04271	Y2H Pooling	32814053
Intra	RAC1	P63000	S100B	Homo sapiens	P04271	Y2H Array	32814053
Intra	RAC1	P63000	UTP14A	Homo sapiens	Q9BVJ6	Validated Y2H	32814053
Intra	RAC1	P63000	UTP14A	Homo sapiens	Q9BVJ6	Y2H Array	32814053
Intra	RAC1	P63000	UTP14A	Homo sapiens	Q9BVJ6	Y2H Pooling	32814053
Intra	RAC1	P63000	BIRC2	Homo sapiens	Q13490	Anti Bait CoIP	22117219
Intra	RAC1	P63000	XIAP	Homo sapiens	P98170	Anti Bait CoIP	22117219
Intra	RAC1	P63000	BAIAP2	Homo sapiens	Q9UQB8	Biosensor	17003044
Intra	RAC1	P63000	BAIAP2	Homo sapiens	Q9UQB8	Pull Down	17003044
Intra	RAC1	P63000	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	21454543
Intra	RAC1	P63000	LRRK2	Homo sapiens	Q5S007	Confocal	21454543
Intra	RAC1	P63000	OCRL	Homo sapiens	Q01968	Anti Bait CoIP	12915445
Intra	RAC1	P63000	GABPB1	Homo sapiens	Q06547-2	Validated Y2H	32814053
Intra	RAC1	P63000	GABPB1	Homo sapiens	Q06547-2	Y2H Array	32814053
Intra	RAC1	P63000	GABPB1	Homo sapiens	Q06547-2	Y2H Pooling	32814053
Intra	RAC1	P63000	VAV1	Homo sapiens	P15498	Fluorescence	18511940
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	Y2H	8670882
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	SLC	31467278
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	Complementation	31467278
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	MAPPIT	31467278
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	BRET	29997244
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	Beta Galactosidase	9312003
Intra	RAC1	P63000	ARFIP2	Homo sapiens	P53365	X-Ray Diffraction	11346801
Intra	RAC1	P63000	PNP	Homo sapiens	P00491	Validated Y2H	32814053
Intra	RAC1	P63000	PNP	Homo sapiens	P00491	Y2H Pooling	32814053
Intra	RAC1	P63000	PNP	Homo sapiens	P00491	Y2H Array	32814053
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	Anti Tag CoIP	31980649
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	Y2H	21900206
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	Pull Down	17245428
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	Anti Tag CoIP	35271311
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	Pull Down	22157745
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	X-Ray Diffraction	11513578
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	Anti Tag CoIP	22157745
Intra	RAC1	P63000	ARHGDIA	Homo sapiens	P52565	TAP	27173435
Intra	RAC1	P63000	ARHGEF7	Homo sapiens	Q14155	Pull Down	16492808
Intra	RAC1	P63000	ARHGEF7	Homo sapiens	Q14155	Pull Down	24792722
Intra	RAC1	P63000	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	RAC1	P63000	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	RAC1	P63000	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	RAC1	P63000	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	RAC1	P63000	KCTD17	Homo sapiens	Q8N5Z5	Y2H Pooling	32814053
Intra	RAC1	P63000	KCTD17	Homo sapiens	Q8N5Z5	Validated Y2H	32814053
Intra	RAC1	P63000	KCTD17	Homo sapiens	Q8N5Z5	Y2H Array	32814053
Intra	RAC1	P63000	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	33961781
Intra	RAC1	P63000	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	35271311
Intra	RAC1	P63000	RAP1GDS1	Homo sapiens	P52306	Anti Tag CoIP	31980649
Intra	RAC1	P63000	NAA10	Homo sapiens	P41227	Y2H Pooling	32814053
Intra	RAC1	P63000	NAA10	Homo sapiens	P41227	Validated Y2H	32814053
Intra	RAC1	P63000	NAA10	Homo sapiens	P41227	Y2H Array	32814053
Intra	RAC1	P63000	PLCG1	Homo sapiens	P19174	Anti Bait CoIP	19264842
Intra	RAC1	P63000	PLCG1	Homo sapiens	P19174	Anti Tag CoIP	19264842
Intra	RAC1	P63000	SH3RF3	Homo sapiens	Q8TEJ3	Anti Tag CoIP	20696164
Intra	RAC1	P63000	PARD6A	Homo sapiens	Q9NPB6	Y2H	11260256
Intra	RAC1	P63000	PARD6A	Homo sapiens	Q9NPB6	Pull Down	11260256
Intra	RAC1	P63000	JUN	Homo sapiens	P05412	Y2H Array	32814053
Intra	RAC1	P63000	JUN	Homo sapiens	P05412	Y2H Pooling	32814053
Intra	RAC1	P63000	JUN	Homo sapiens	P05412	Validated Y2H	32814053
Intra	RAC1	P63000	TNFAIP8L2	Homo sapiens	Q6P589	Anti Tag CoIP	24274578
Intra	RAC1	P63000	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	RAC1	P63000	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Intra	RAC1	P63000	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Cross	RAC1	P63000	smc	Mycoplasma pulmonis	Q98PK8	Confocal	24172987

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74608	RAC1 Protein, Human (sf9, GST)	P63000-1 (M1-C189)	≥ 95%, as determined by reducing SDS-PAGE.

RAC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810820	Rac 1 Antibody (YA10063)	WB, IHC-P, FC	Human, Rat

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 48	Mental Retardation, Autosomal Dominant 48 MRD48 Autosomal Dominant Mental Retardation 48 Autosomal Dominant Intellectual Developmental Disorder 48
Microcephaly-Corpus Callosum And Cerebellar Vermis Hypoplasia-Facial Dysmorphism-Intellectual Disability Syndrom
Skin Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Skin Epidermoid Skin Carcinoma Squamous Cell Carcinoma Of The Skin Squamous Cell Epithelioma Of Skin Cutaneous Squamous Cell Carcinoma Scc - [Squamous Cell Carcinoma] Of Skin
Chlamydia	Chlamydial Infection Chlamydia Trachomatis Infectious Disease Chlamydial Disease Chlamydia Infections
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Neurofibroma	Neurofibromas Neurofibromatoses Nerve Sheath Tumors
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Polyposis Syndrome, Hereditary Mixed, 1	HMPS1 Colorectal Adenoma And Carcinoma 1 Crac1 Colorectal Cancer 4 Chromosome 15q13-Q14 Duplication Syndrome, 40-Kb Colorectal Cancer, Susceptibility To, 4 Hereditary Mixed Polyposis Syndrome 1 Polyposis Syndrome, Hereditary Mixed 1 CRCS4 Susceptibility To Colorectal Cancer On Chromosome 15 Polyposis Syndrome, Mixed Hereditary 1 Adenomatous Polyps
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10071A	Y-27632 hydrochloride hydrate		99.65%	Phase 3
HY-112842	MBQ-167	Inhibitor	99.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (95)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10071	Y-27632		99.91%	Unkown
HY-18723	Yoda 1		99.97%	Unkown
HY-15723A	NSC 23766 trihydrochloride		99.41%	Unkown
HY-12755	ML141		99.96%	Unkown
HY-12646	Rhosin hydrochloride		99.94%	Unkown
HY-16659	EHT 1864	Inhibitor	99.85%	Unkown
HY-12810	EHop-016	Inhibitor	99.38%	Unkown
HY-125792	Nexinhib20	Inhibitor	99.86%	Unkown
HY-12646A	Rhosin		98.74%	Unkown
HY-100047	Nα,Nα-Bis(carboxymethyl)-L-lysine		98.80%	Unkown
HY-124306	ML-099	Activator	99.75%	Unkown
HY-110100	CPYPP	Inhibitor	99.80%	Unkown
HY-104064	1A-116		99.72%	Unkown
HY-115376	Z62954982	Inhibitor	99.38%	Unkown
HY-N0710	alpha-Cyperone		99.68%	Unkown
HY-U00145	Digeranyl bisphosphonate	Inhibitor	99.07%	Unkown
HY-107501	(Rac)-1-Oleoyl lysophosphatidic acid sodium		98.0%	Unkown
HY-113849	MLS-573151	Inhibitor	99.66%	Unkown
HY-118208	ML-097	Inhibitor	99.90%	Unkown
HY-136383	AZA1		98.17%	Unkown
HY-111355	Cholesterol sulfate		98.49%	Unkown
HY-119576	Phox-I2	Inhibitor	99.46%	Unkown
HY-B0580B	(R)-Ketorolac	Inhibitor	99.35%	Unkown
HY-106381	Aurothiomalate sodium	Inhibitor	98.0%	Unkown
HY-102078	ZINC69391		99.12%	Unkown
HY-15031	l-Naproxen	Inhibitor	99.63%	Unkown
HY-175341	Rac1-IN-5	Inhibitor	99.84%	Unkown
HY-112307A	(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium		99.97%	Unkown
HY-133146	DJ001	Inhibitor	99.92%	Unkown
HY-158304	Rac1-IN-4	Inhibitor	98.61%	Unkown
HY-106381A	Aurothiomalate tetramer sodium	Inhibitor	98.0%	Unkown
HY-120213	YH-306		98.34%	Unkown
HY-143699S	(Rac)-1,2-Bis-palmitol-3-chloropropanediol-d5		98.51%	Unkown
HY-50733A	CX-5011		99.48%	Unkown
HY-P10038A	mP6 TFA	Inhibitor	98.48%	Unkown
HY-121667	Scaff10-8	Inhibitor	99.11%	Unkown
HY-131598C	6-Thio-GTP tetrasodium	Inhibitor	99.7%	Unkown
HY-156668	Rac1-IN-3	Inhibitor	98.94%	Unkown
HY-P1382A	Rac1 Inhibitor W56 TFA	Inhibitor	99.92%	Unkown
HY-RS11591	RAC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W127391	1,2-Dilaurin		98.0%	Unkown
HY-152095	PPI-GIT1/β-Pix PPI-IN-1	Inhibitor	99.01%	Unkown
HY-180801	E8431		97.34%	Unkown
HY-W013060	(Rac)-1,2-Dilinoleoyl-3-palmitoyl-glycerol		99.0%	Unkown
HY-W127550	1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium		/	Unkown
HY-50733	CX-5011 free base		/	Unkown
HY-W778471	rac-1-Linoleoyl-3-linolenoyl-propanetriol		98.64%	Unkown
HY-115507	NMac1		/	Unkown
HY-109541S6	(Rac)-Colfosceril miristate-d72		/	Unkown
HY-120229	GGTI-2147	Inhibitor	/	Unkown
HY-137862A	(Rac)-1-Oleoyl lysophosphatidic acid	Control	/	Unkown
HY-144624	PROTAC Axl Degrader 1		/	Unkown
HY-146841S1	(Rac)-Lysophosphatidylcholine C19:0-d5		/	Unkown
HY-147076	20:4 PG sodium		/	Unkown
HY-170458	18:0-18:2 PG sodium		/	Unkown
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	Unkown
HY-180371	NF-115	Inducer	/	Unkown
HY-183246	Rac/Cdc42-IN-1	Inhibitor	/	Unkown
HY-184184	Axl ligand-1	Ligand	/	Unkown
HY-E70632	PIP5K1B Recombinant Human Active Lipid Kinase		/	Unkown
HY-N8960A	(Rac)-1-Hydroxybisabola-2,10-dien-4-one		/	Unkown
HY-P10038	mP6	Inhibitor	/	Unkown
HY-P10107	TAT-PAK18 R192A	Control	/	Unkown
HY-P11092	TLQP-62 (mouse,rat)		/	Unkown
HY-P1382	Rac1 Inhibitor W56	Inhibitor	/	Unkown
HY-P1383A	Rac1 Inhibitor F56, control peptide TFA	Inhibitor	/	Unkown
HY-RS12018	RNASE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W010270A	Aurothiomalate disodium	Inhibitor	/	Unkown
HY-W127356	(Rac)-1,2-Distearoyl-3-chloropropanediol-d5		/	Unkown
HY-W127363	(Rac)-1,2-Dihexadecylglycerol		/	Unkown
HY-W127415	(Rac)-1-Stearoyl-3-chloropropanediol		/	Unkown
HY-W127415S	(Rac)-1-Stearoyl-3-chloropropanediol-d5		/	Unkown
HY-W127415S1	(Rac)-1-Stearoyl-3-chloropropanediol-d5-1		/	Unkown
HY-W127570	rac-1,2-Distearoyl-3-chloropropanediol		/	Unkown
HY-W587715S	(Rac)-1,2-Dioleoyl-3-chloropropanediol-d5		/	Unkown
HY-W653931	rac 1,2-Bis-palmitoyl-3-chloropropanediol-13C3		/	Unkown
HY-W749785	rac-1-Lauroyl-2-decanoyl-3-chloropropanediol-d5		/	Unkown
HY-W766801	1-Linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W766802	rac-1-Linoleoyl-2-linolenoyl-3-chloropropanediol-d5		/	Unkown
HY-W767222	rac-1-Linoleoyl-2-chloropropanediol-d5		/	Unkown
HY-W767223	rac 1-Palmitoyl-2-chloropropanediol-d5		/	Unkown
HY-W770200	rac 1-Oleoyl-2,3-isopropylidieneglycerol-d5		/	Unkown
HY-W777103	(Rac)-1-Oleoyl-3-linoleoyl-glycerol		/	Unkown
HY-W777682	(Rac)-1-Linoleoyl-2,3-isopropylidene-glycerol		/	Unkown
HY-W777871	rac-1-Palmitoyl-2-linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-134243	6-T-GDP	Inhibitor	/	Unkown
HY-181864	Rac1-IN-6	Inhibitor	/	Unkown
HY-RS16742	Rac1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23179	Rac1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W702728	rac 1-Palmitoyl-2-chloropropanediol		/	Unkown
HY-W749756	rac-1,2-Distearoyl-3-chloropropanediol-13C3		/	Unkown
HY-W766807	rac-1,2-Dilinoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W766831	rac 1-oleoyl-2-linoleoyl-3-chloropropanediol-d5		/	Unkown
HY-W777865	1-Linoleoyl-3-chloropropanediol		/	Unkown
HY-W777866	(Rac)-1-Linoleoyl-2-stearoyl-3-chloropropanediol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAC1	VGNC	VGNC:106889
Mus musculus	RAC1	MGD	MGI:97845
Macaca mulatta	RAC1	VGNC	VGNC:108433
Rattus norvegicus	RAC1	RGD	RGD:619755
Felis catus	RAC1	VGNC	VGNC:80679
Canis familiaris	RAC1	VGNC	VGNC:49609
Others	RAC1	NCBI