Stat4 - signal transducer and activator of transcription 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 367264

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in nucleus. Used to study obesity. Biomarker of asthma and chronic obstructive pulmonary disease. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; autoimmune disease (multiple); dermatomyositis; genital herpes; and systemic scleroderma (multiple). Orthologous to human STAT4 (signal transducer and activator of transcription 4). [provided by Alliance of Genome Resources, Apr 2022]

Stat4 Products (1)

mRNA Protein Name
NM_001012226.1 NP_001012226.1 signal transducer and activator of transcription 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16648019 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19414010 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19414010 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal transducer and activator of transcription 4

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109854A (R)-Lisofylline Inhibitor 99.99% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-N0204 Pulchinenoside A Activator 98.81% Unkown
HY-161464 Chlopynostat 98.36% Unkown
HY-173357 TYD-68 99.54% Unkown
HY-172946 SD-2301 Degrader / Unkown
HY-RS13891 STAT4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-150895 SI-191 Ligand / Unkown
HY-RS17148 Stat4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23597 Stat4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat4 NCBI NCBI:6775