TBC1D10C - TBC1 domain family member 10C Gene

Also Known as EPI64C; CARABIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374403

Summary

The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for Calcineurin, and is an inhibitor of both the Ras signaling pathway and Calcineurin, a Phosphatase regulated by calcium and Calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Biased expression in lymph node (RPKM 27.2), spleen (RPKM 25.6) and 10 other tissues.

TBC1D10C Products (8)

mRNA Protein Name
NM_001256508.1 NP_001243437.1 carabin isoform 2
NM_001369492.1 NP_001356421.1 carabin isoform 3
NM_001369494.1 NP_001356423.1 carabin isoform 4
NM_001369495.1 NP_001356424.1 carabin isoform 4
NM_001369496.1 NP_001356425.1 carabin isoform 1
NM_001369497.1 NP_001356426.1 carabin isoform 1
NM_001369498.1 NP_001356427.1 carabin isoform 5
NM_198517.4 NP_940919.1 carabin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Références Source
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
17562788 GOA
Cellular Component GO Annotation Evidence Références Source
located in filopodium membrane IDA
IDA: Inferred from direct assay
17562788 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17562788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBC1D10C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TBC1D10C Q8IV04 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
TBC1D10C Q8IV04 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
TBC1D10C Q8IV04 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
TBC1D10C Q8IV04 HOXA1 Homo sapiens P49639
Y2H Array
25416956
Intra
TBC1D10C Q8IV04 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
TBC1D10C Q8IV04 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
25416956
Intra
TBC1D10C Q8IV04 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra
TBC1D10C Q8IV04 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra
TBC1D10C Q8IV04 KLHL12 Homo sapiens Q53G59
Validated Y2H
25416956
Intra
TBC1D10C Q8IV04 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14231 TBC1D10B Human Pre-designed siRNA Set A Pre-designed Set / Unkown