ARL4D - ADP ribosylation factor like GTPase 4D Gene

Also Known as ARF4L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 379

About ARL4D

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,398,993-43,401,137 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 30 paralogues. Broad expression in thyroid (RPKM 16.5), esophagus (RPKM 15.6) and 20 other tissues.

Summary

ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021]

ARL4D Products (1)

mRNA Protein Name
NM_001661.4 NP_001652.2 ADP-ribosylation factor-like protein 4D

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17398095 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17398095 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17398095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylation factor-like protein 4D

  • ADP-ribosylation factor-like 4D

ARL4D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARL4D P49703 CCDC102B Homo sapiens Q68D86
Anti Tag CoIP
25416956
Intra
ARL4D P49703 CCDC102B Homo sapiens Q68D86
Validated Y2H
25416956
Intra
ARL4D P49703 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bardet-Biedl Syndrome 3

  • BBS3

  • Bardet-Biedl Syndrome, Type 3
Noonan Syndrome 13

  • NS13
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00990 ARL4D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ARL4D VGNC VGNC:70001
Canis familiaris ARL4D VGNC VGNC:38114
Rattus norvegicus ARL4D RGD RGD:1306875
Bos taurus ARL4D VGNC VGNC:26146
Mus musculus ARL4D MGD MGI:1933155
Others ARL4D NCBI