LCP1 - lymphocyte cytosolic protein 1 Gene

Homo sapiens

Also known as LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN

Gene ID: 3936 | Gene type: protein coding

About LCP1

Cytogenetic location: 13q14.13 Genomic coordinates (GRCh38): 13:46,125,923-46,182,177 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues, 2 paralogues and is associated with 63 phenotypes. Broad expression in lymph node (RPKM 278.7), bone marrow (RPKM 256.8) and 18 other tissues.

Summary

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]

LCP1 Products(1)

mRNA	Protein	Name
NM_002298.5	NP_002289.2	plastin-2

LCP1 Protein Structure

EF-hand_7

0
100
200
300
400
500
627 a.a.

Protein Preferred Names

Protein Names

plastin-2

L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)

Recombinant LCP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71750	LCP1 Protein, Human (P.pastoris, His)	P13796 (2A-627V)	≥95%

Related Diseases

Diseases

Alias

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

B-Cell Non-Hodgkin Lymphoma

B-Cell Nhl

B-Cell Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07563	LCP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LCP1	MGD	MGI:104808
Canis familiaris	LCP1	VGNC	VGNC:42614
Rattus norvegicus	LCP1	RGD	RGD:1308288
Bos taurus	LCP1	VGNC	VGNC:30817
Felis catus	LCP1	VGNC	VGNC:68024
Macaca mulatta	LCP1	VGNC	VGNC:74242
Others	LCP1	NCBI