Gfral - GDNF family receptor alpha like Gene

Also Known as Gral

Species: Mus musculus

Gene Type: protein coding

Gene ID: 404194

Summary

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in positive regulation of MAPK cascade and reduction of food intake in response to dietary excess. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of neuron apoptotic process; and stress-activated protein kinase signaling cascade. Located in plasma membrane. Orthologous to human GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Apr 2022]

Gfral Products (1)

mRNA	Protein	Name
NM_205844.4	NP_995316.2	GDNF family receptor alpha-like precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glial cell-derived neurotrophic factor receptor activity	IDA IDA: Inferred from direct assay	28846097	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28846098	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	28846099	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in GDF15-GFRAL signaling pathway	IDA IDA: Inferred from direct assay	32723474	MGI
involved in GDF15-GFRAL signaling pathway	IMP IMP: Inferred from mutant phenotype	31875646	MGI
involved in negative regulation of appetite	IDA IDA: Inferred from direct assay	32723474	MGI
involved in negative regulation of appetite	IMP IMP: Inferred from mutant phenotype	31875646	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	16086688	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16086688	MGI
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	28953886	MGI
involved in reduction of food intake in response to dietary excess	IDA IDA: Inferred from direct assay	28846097	MGI
involved in reduction of food intake in response to dietary excess	IMP IMP: Inferred from mutant phenotype	28846098	MGI
involved in response to metformin	IMP IMP: Inferred from mutant phenotype	31875646	MGI
acts upstream of or within stress-activated protein kinase signaling cascade	IDA IDA: Inferred from direct assay	16086688	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16086688	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
GDNF family receptor alpha-like	GDNF receptor alpha-like

Recombinant Gfral Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77947	GFRAL Protein, Mouse (HEK293, His-Avi)	Q6SJE0-1 (Q20-E350)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P700449	GFRAL Protein, Mouse (HEK293, His-Myc)	Q6SJE0-1 (Q20-G349)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700728	GFRAL Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q6SJE0-1 (Q20-E350)	≥ 95%, as determined by reducing Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99241	Ponsegromab	Inhibitor	99.60%	Phase 3
HY-P990635	NGM-120	Inhibitor	99.28%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W587486	N-Acetyltaurine		99.91%	Unkown
HY-W587486R	N-Acetyltaurine (Standard)	Activator	99.33%	Unkown
HY-RS05390	GFRAL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17340	Gfral Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23795	Gfral Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W587486A	N-Acetyltaurine hemimagnesium		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992393	JMT203		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gfral	NCBI	NCBI:389400