LTF - lactotransferrin Gene
Also Known as LF; HLF2; GIG12; HEL110
Species: Homo sapiens
About LTF
This gene has 9 transcripts (splice variants), 217 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 1214.2), salivary gland (RPKM 176.0) and 2 other tissues.
Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against Cancer development and metastasis. Antimicrobial, Antiviral, Antifungal and antiparasitic activity has been found for this protein and its peptides. Activity against both DNA and RNA viruses has been found, including activity against SARS-CoV-2, and HIV. [provided by RefSeq, Jul 2021]
LTF Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001199149.2 | NP_001186078.1 | lactotransferrin isoform 2 |
| NM_001321121.2 | NP_001308050.1 | lactotransferrin isoform 3 preproprotein |
| NM_001321122.2 | NP_001308051.1 | lactotransferrin isoform 4 |
| NM_002343.6 | NP_002334.2 | lactotransferrin isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cysteine-type endopeptidase inhibitor activity |
IDA
IDA: Inferred from direct assay
|
12788072 | GOA |
| enables heparin binding |
IDA
IDA: Inferred from direct assay
|
11907569 | GOA |
| enables iron ion binding |
IDA
IDA: Inferred from direct assay
|
12037568 | GOA |
| enables lipopolysaccharide binding |
IDA
IDA: Inferred from direct assay
|
9596699 | GOA |
| enables lipopolysaccharide binding |
IMP
IMP: Inferred from mutant phenotype
|
15155221 | GOA |
| enables membrane destabilizing activity |
IMP
IMP: Inferred from mutant phenotype
|
15155221 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
1544444 | GOA |
| enables protein serine/threonine kinase activator activity |
IDA
IDA: Inferred from direct assay
|
20345905 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
17567961 | GOA |
| located in cytoplasm |
IMP
IMP: Inferred from mutant phenotype
|
25193851 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
12788072 | GOA |
| part of protein-containing complex |
IDA
IDA: Inferred from direct assay
|
17567961 | GOA |
| located in secretory granule |
IDA
IDA: Inferred from direct assay
|
11907569 | GOA |
| located in specific granule |
IDA
IDA: Inferred from direct assay
|
2981589 | GOA |
LTF Protein Structure
Transferrin: Transferrin (25 - 352)
Transferrin: Transferrin (364 - 695)
- 0
- 200
- 400
- 600
- 710 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
lactotransferrin |
|
LTF Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Cross
|
LTF | P02788 | CALM | Bos taurus | P62157 | 1544444 | |
|
Cross
|
LTF | P02788 | CALM | Bos taurus | P62157 | 1544444 | |
|
Cross
|
LTF | P02788 | P27958-PRO_0000037569 | Hepatitis C virus | P27958-PRO_0000037569 | 9223490 | |
|
Cross
|
LTF | P02788 | P27958-PRO_0000037570 | Hepatitis C virus | P27958-PRO_0000037570 | 9223490 | |
|
Cross
|
LTF | P02788 | P27958-PRO_0000037570 | Hepatitis C virus | P27958-PRO_0000037570 | 9223490 | |
|
Cross
|
LTF | P02788 | P27958-PRO_0000037570 | Hepatitis C virus | P27958-PRO_0000037570 | 12522210 |
Recombinant LTF Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70156 | Lactoferrin/LTF Protein, Human (691a.a, HEK293, His) | AAH15822.1 (G20-K711) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P74790 | Lactoferrin/LTF Protein, Human (HEK293, His) | P02788-1 (G20-K710) | ≥ 95%, as determined by reducing SDS-PAGE. |
LTF Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82529 | Lactoferrin Antibody (YA2274) | WB, ICC/IF, IP | Human |
| HY-P85683 | Lactoferrin Antibody (YA5375) | ICC/IF, IHC-P, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mastitis |
|
|
| Keratoconjunctivitis Sicca |
|
|
| Dry Eye Syndrome |
|
|
| Oral Candidiasis |
|
|
| Shigellosis |
|
|
| Pouchitis |
|
|
| Gingivitis |
|
|
| Dental Caries |
|
|
| Specific Granule Deficiency 1 |
|
|
| Reactive Arthritis |
|
|
| Iron Deficiency Anemia |
|
|
| Bacterial Vaginosis |
|
|
| Haemophilus Influenzae |
|
|
| Perinatal Necrotizing Enterocolitis |
|
|
| Vasculitis |
|
|
| Sjogren Syndrome |
|
|
| Corneal Dystrophy, Gelatinous Drop-Like |
|
|
| Siderosis |
|
|
| Proctitis |
|
|
| Dysentery |
|
|
| Blepharitis |
|
|
| Bronchitis |
|
|
| Candidiasis |
|
|
| Male Infertility |
|
|
| Parotitis |
|
|
| Protein-Energy Malnutrition |
|
|
| Rheumatoid Vasculitis |
|
|
| Keratoconjunctivitis |
|
|
| Aggressive Periodontitis |
|
|
| Gastritis |
|
|
| Periodontitis, Aggressive, 1 |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Conjunctivitis |
|
|
| Colitis |
|
|
| Inflammatory Bowel Disease |
|
|
| Monocytic Leukemia |
|
|
| Infertility |
|
|
| Cystic Fibrosis |
|
|
| Bacterial Infectious Disease |
|
|
| Onchocerciasis |
|
|
| Osteogenesis Imperfecta, Type Xxi |
|
|
| Aplasia Of Lacrimal And Salivary Glands |
|
|
| Chronic Granulomatous Disease |
|
|
| Peripheral Vascular Disease |
|
|
| Rheumatoid Arthritis |
|
|
| Severe Congenital Neutropenia |
|
|
| Malaria |
|
|
| Salivary Gland Disease |
|
|
| Crohn'S Disease |
|
|
| Systemic Lupus Erythematosus |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Connective Tissue Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | LTF | RGD | RGD:1305445 |
| Bos taurus | LTF | VGNC | VGNC:31077 |
| Mus musculus | LTF | MGD | MGI:96837 |
| Macaca mulatta | LTF | VGNC | VGNC:74460 |
| Felis catus | LTF | VGNC | VGNC:68108 |
| Canis familiaris | LTF | VGNC | VGNC:42861 |
| Others | LTF | NCBI |