MC5R - melanocortin 5 receptor Gene

Also Known as MC2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4161

About MC5R

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,824,149-13,827,323 (from NCBI)

This gene has 2 transcripts (splice variants), 183 orthologues and 18 paralogues.

Summary

This gene encodes a member of the seven-pass transmembrane G protein-coupled Melanocortin Receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

MC5R Products (1)

mRNA Protein Name
NM_005913.3 NP_005904.1 melanocortin receptor 5

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19329486 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19329486 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MC5R Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (53 - 295)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

melanocortin receptor 5

MC5R Antibodies

Cat. No. Product Name Application Reactivity
HY-P86958 MC-2 Antibody (YA6651) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Hypoactive Sexual Desire Disorder

  • Lack Or Loss Of Sexual Desire

  • Sexual Dysfunctions, Psychological
Autoimmune Disease Of Eyes, Ear, Nose And Throat
Familial Glucocorticoid Deficiency

  • Glucocorticoid Deficiency

  • Acth Resistance

  • Adrenal Unresponsiveness To Acth

  • Hereditary Unresponsiveness To Adrenocorticotropic Hormone

  • Isolated Glucocorticoid Deficiency

  • Glucocorticoid Deficiency, Familial

  • Glucocorticoid Deficiency 1
Autoimmune Uveitis
Schizophrenia 4

  • SCZD4

  • Schizophrenia, Susceptibility To, 4

  • Schizophrenia Susceptibility Locus, Chromosome 22q11-Related

  • Schizophrenia Susceptibility Locus Chromosome 22-Related

  • Schizophrenia, Type 4
Fundus Dystrophy

  • Retinal Dystrophy

  • Retinal Dystrophies

  • Dystrophy, Retinal
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107139 JNJ-10229570 Antagonist 98.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0227 SHU 9119 99.83% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 95.58% Unkown
HY-P0097 Nonapeptide-1 Antagonist 98.74% Unkown
HY-19870C Setmelanotide monoacetate Agonist 99.81% Unkown
HY-P11469 PG-901 Modulator 99.35% Unkown
HY-P4665 Ac-c[Cys-Glu-His-d-Phe-Arg-Trp-d-Cys]-Pro-Pro-Lys-Asp-NH2 Antagonist 98.14% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MC5R VGNC VGNC:43068
Felis catus MC5R VGNC VGNC:68206
Rattus norvegicus MC5R RGD RGD:3058
Mus musculus MC5R MGD MGI:99420
Bos taurus MC5R VGNC VGNC:31296