MC5R - melanocortin 5 receptor Gene

Homo sapiens

Also known as MC2

Gene ID: 4161 | Gene type: protein coding

About MC5R

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,824,149-13,827,323 (from NCBI)

This gene has 2 transcripts (splice variants), 183 orthologues and 18 paralogues.

Summary

This gene encodes a member of the seven-pass transmembrane G protein-coupled Melanocortin Receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]

MC5R Products(1)

mRNA	Protein	Name
NM_005913.3	NP_005904.1	melanocortin receptor 5

MC5R Protein Structure

7tm_1

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

melanocortin receptor 5

Related Diseases

Diseases

Alias

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Autoimmune Disease Of Eyes, Ear, Nose And Throat

Familial Glucocorticoid Deficiency

Glucocorticoid Deficiency	Acth Resistance
Adrenal Unresponsiveness To Acth	Hereditary Unresponsiveness To Adrenocorticotropic Hormone
Isolated Glucocorticoid Deficiency	Glucocorticoid Deficiency, Familial
Glucocorticoid Deficiency 1

Autoimmune Uveitis

Schizophrenia 4

SCZD4	Schizophrenia, Susceptibility To, 4
Schizophrenia Susceptibility Locus, Chromosome 22q11-Related	Schizophrenia Susceptibility Locus Chromosome 22-Related
Schizophrenia, Type 4

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.95%	Unkown
HY-P0097A	Nonapeptide-1 acetate salt	Antagonist	98.70%	Unkown
HY-P0097	Nonapeptide-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MC5R	VGNC	VGNC:43068
Felis catus	MC5R	VGNC	VGNC:68206
Rattus norvegicus	MC5R	RGD	RGD:3058
Mus musculus	MC5R	MGD	MGI:99420
Bos taurus	MC5R	VGNC	VGNC:31296

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