MELTF - melanotransferrin Gene

Also Known as MTf; MFI2; MTF1; CD228; MAP97

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4241

About MELTF

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:197,001,740-197,029,817 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in salivary gland (RPKM 9.5), kidney (RPKM 5.4) and 16 other tissues.

Summary

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

MELTF Products (2)

mRNA Protein Name
NM_005929.6 NP_005920.2 melanotransferrin isoform 1 preproprotein
NM_033316.4 NP_201573.1 melanotransferrin isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables iron ion binding IMP
IMP: Inferred from mutant phenotype
7556058 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19815549 GOA
Biological Process GO Annotation Evidence References Source
involved in iron ion transport IMP
IMP: Inferred from mutant phenotype
7556058 GOA
involved in negative regulation of substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
16713448 GOA
involved in positive regulation of extracellular matrix disassembly IDA
IDA: Inferred from direct assay
16713448 GOA
involved in positive regulation of plasminogen activation IDA
IDA: Inferred from direct assay
16713448 GOA
NOT involved in regulation of cell growth IMP
IMP: Inferred from mutant phenotype
7556058 GOA
NOT involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
7556058 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
7556058 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
7556058 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MELTF Protein Structure

Transferrin

Transferrin: Transferrin (23 - 356)

Transferrin

Transferrin: Transferrin (366 - 704)

  • 0
  • 200
  • 400
  • 600
  • 738 a.a.
Protein Preferred Names Protein Names

melanotransferrin

  • antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

Recombinant MELTF Proteins

Cat. No. Product Name Accession Purity
HY-P700671 Melanotransferrin/CD228 Protein, Human (HEK293, His) P08582-1 (G20-C709) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Osteogenic Sarcoma

  • Osteosarcoma

  • OSRC

  • Osteosarcoma, Somatic

  • Neoplasms, Bone Tissue

  • Bone Tissue Neoplasm

  • Osteoid Sarcoma

  • Skeletal Sarcoma

  • Osteosarcoma Of Bone

  • Bone Sarcoma
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Melanotic Neuroectodermal Tumor

  • Melanotic Neuroectodermal Tumor Of Infancy

  • Neuroectodermal Tumor, Melanotic

  • Infantile Melanotic Neuroectodermal Neoplasm

  • Melanotic Neuroectodermal Tumour

  • Melanotic Neuroectodermal Tumour Of Infancy

  • Pigmented Neuroectodermal Tumour Of Infancy
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08331 MELTF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20054 Meltf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26558 Meltf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MELTF VGNC VGNC:31383
Felis catus MELTF VGNC VGNC:68243
Rattus norvegicus MELTF RGD RGD:1308155
Mus musculus MELTF MGD MGI:1353421
Canis familiaris MELTF VGNC VGNC:43155
Macaca mulatta MELTF VGNC VGNC:74711
Others MELTF NCBI