MYO1B - myosin IB Gene

Homo sapiens

Also known as MMIa; myr1; MYH-1c; MMI-alpha

Gene ID: 4430 | Gene type: protein coding

About MYO1B

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:191,245,404-191,425,386 (from NCBI)

This gene has 15 transcripts (splice variants), 211 orthologues and 43 paralogues. Broad expression in liver (RPKM 53.1), lung (RPKM 45.2) and 23 other tissues.

Summary

Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Involved in actin filament organization and post-Golgi vesicle-mediated transport. Located in several cellular components, including actin filament; endosome; and perinuclear region of cytoplasm. Colocalizes with trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

MYO1B Products(5)

mRNA	Protein	Name
NM_001130158.3	NP_001123630.1	unconventional myosin-Ib isoform 1
NM_001161819.3	NP_001155291.1	unconventional myosin-Ib isoform 1
NM_001330237.2	NP_001317166.1	unconventional myosin-Ib isoform 4
NM_001330238.2	NP_001317167.1	unconventional myosin-Ib isoform 5
NM_012223.5	NP_036355.2	unconventional myosin-Ib isoform 2

MYO1B Protein Structure

Myosin_head

Myosin_TH1

0
200
400
600
800
1000
1136 a.a.

Protein Preferred Names

Protein Names

unconventional myosin-Ib

MYO1B variant protein

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Deafness, Autosomal Dominant 48

DFNA48	Autosomal Dominant Nonsyndromic Deafness 48
Autosomal Dominant Deafness 48	Deafness, Autosomal Dominant, 48
Deafness Autosomal Dominant Due To Mutation In Myo1a	Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 48
Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 48	Deafness, Autosomal Dominant, Type 48

Scrotum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Scrotum

Scrotal Squamous Cell Carcinoma

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Primary Amebic Meningoencephalitis

Pam	Naegleria Fowleri Infection
Meningoencephalitis Caused By Naegleria Fowleri	Primary Amoebic Meningoencephalitis

Scrotal Carcinoma

Carcinoma Of Scrotum	Malignant Neoplasm Of Scrotum
Neoplasm Of Scrotum

Amebiasis

Amoebiasis	Entamoebiasis
Chronic Intestinal Amebiasis	Amoebiasis, Unspecified
Amebic Colitis	Amoebic Enteritis
Infection Due To Entamoeba Histolytica	Amoebic Infection
Disease Due To Endamoebidae	Amoebiasis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08938	MYO1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MYO1B	MGD	MGI:107752
Bos taurus	MYO1B	VGNC	VGNC:31817
Canis familiaris	MYO1B	VGNC	VGNC:43561
Macaca mulatta	MYO1B	VGNC	VGNC:75111
Rattus norvegicus	MYO1B	RGD	RGD:70994
Felis catus	MYO1B	VGNC	VGNC:68389

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