MEF2C - Mef2c myocyte enhancer factor 2C Gene

Also Known as RGD1563119

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 499497

Summary

Enables DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to retinoic acid; dentate gyrus development; and transdifferentiation. Located in nucleus and sarcomere. Used to study myocardial infarction. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 20. Orthologous to human MEF2C (myocyte enhancer factor 2C). [provided by Alliance of Genome Resources, Apr 2022]

MEF2C Products (2)

mRNA Protein Name
NM_001399397.1 NP_001386326.1 myocyte-specific enhancer factor 2C isoform 1
NM_001399399.1 NP_001386328.1 myocyte-specific enhancer factor 2C isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11782488 RGD
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19654000 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15485823 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
18413674 RGD
involved in cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
19654000 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
11073966 RGD
involved in cellular response to retinoic acid IDA
IDA: Inferred from direct assay
17568621 RGD
involved in dentate gyrus development IEP
IEP: Inferred from expression pattern
18949272 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
15486975 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
19103177 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19654000 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17696759 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
19103177 RGD
involved in positive regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
19654000 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19654000 RGD
involved in response to ischemia IDA
IDA: Inferred from direct assay
19103177 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
20676734 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
16534476 RGD
involved in transdifferentiation IMP
IMP: Inferred from mutant phenotype
23948075 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19103177 RGD
located in nucleus IDA
IDA: Inferred from direct assay
15862299 RGD
located in sarcomere IDA
IDA: Inferred from direct assay
15862299 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myocyte-specific enhancer factor 2C

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120877 MRT199665 99.85% Unkown
HY-164288 TDI-6570 Inhibitor 99.64% Unkown
HY-120877A (R)-MRT199665 98.70% Unkown
HY-122610 VUT-MK142 Activator 99.57% Unkown
HY-RS08311 MEF2C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170237 SIK2/3-IN-1 Inhibitor / Unkown
HY-184954 SIK-IN-6 Inhibitor / Unkown
HY-174479 Mouse Mef2c mRNA / Unkown
HY-174583 Human MEF2C mRNA / Unkown
HY-RS19021 Mef2c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25510 Mef2c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens MEF2C NCBI NCBI:4208