Mapk9 - mitogen-activated protein kinase 9 Gene

Also Known as SAPK

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50658

About Mapk9

Primary_assembly 10: 34,169,675-34,210,178 forward strand.mRatBN7.2:CM026983.1

This gene has 7 transcripts (splice variants), 221 orthologues, 21 paralogues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 297.8), Liver (RPKM 173.) and 9 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, Apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung Cancer and prostate Cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]

Mapk9 Products (3)

mRNA Protein Name
NM_001270545.1 NP_001257474.1 mitogen-activated protein kinase 9 isoform 3
NM_017322.2 NP_059018.1 mitogen-activated protein kinase 9 isoform 1
NM_001270544.1 NP_001257473.1 mitogen-activated protein kinase 9 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10051439 RGD
enables JUN kinase activity IDA
IDA: Inferred from direct assay
10051439 RGD
enables JUN kinase activity IMP
IMP: Inferred from mutant phenotype
9786861 RGD
enables cysteine-type endopeptidase activator activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
14522843 RGD
enables mitogen-activated protein kinase kinase kinase binding IPI
IPI: Inferred from physical interaction
16006144 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10856240 RGD
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IDA
IDA: Inferred from direct assay
10051439 RGD
involved in JUN phosphorylation IMP
IMP: Inferred from mutant phenotype
16942465 RGD
involved in cellular hyperosmotic response IEP
IEP: Inferred from expression pattern
10950813 RGD
involved in cellular response to UV IMP
IMP: Inferred from mutant phenotype
8875991 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
12534344 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
17568197 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
9513050 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9475517 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
9475517 RGD
involved in neuron development IEP
IEP: Inferred from expression pattern
17568197 RGD
involved in neuron projection development IMP
IMP: Inferred from mutant phenotype
16006144 RGD
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
15504737 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12029621 RGD
involved in positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
16006144 RGD
involved in positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
16942465 RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
14522843 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
10593906 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
10593906 RGD
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: Inferred from mutant phenotype
9786861 RGD
involved in positive regulation of prostaglandin secretion IMP
IMP: Inferred from mutant phenotype
9786861 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16942465 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10051439 RGD
involved in protein targeting to mitochondrion IEP
IEP: Inferred from expression pattern
15504737 RGD
involved in regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
17348686 RGD
involved in regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
8875991 RGD
involved in release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
15504737 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
18081878 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
16041628 RGD
involved in response to nerve growth factor IEP
IEP: Inferred from expression pattern
11356687 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
18081878 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
15504737 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
14522843 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18385140 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
10950813 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk9 Protein Structure

STKc_JNK

STKc_JNK: cd07850 (24 - 359)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 9

  • MAP kinase 9

  • MAPK 9

  • SAPK-alpha

  • c-Jun N-terminal kinase 2

  • p54-alpha

  • stress activated protein kinase alpha II

  • stress-activated protein kinase JNK2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-RS08127 MAPK9 Human Pre-designed siRNA Set A / Unkown
HY-RS08128 Mapk9 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08129 Mapk9 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk9 NCBI NCBI:5601