Mapk3 - mitogen activated protein kinase 3 Gene

Also Known as p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 50689

About Mapk3

Primary_assembly 1: 181,366,637-181,372,863 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 197 orthologues, 21 paralogues and is associated with 67 phenotypes. Biased expression in Lung (RPKM 21.4), Brain (RPKM 14.7) and 9 other tissues.

Summary

Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonic acid metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytosol; and nucleoplasm. Part of protein-containing complex. Used to study gastric ulcer; middle cerebral artery infarction; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Mapk3 Products (1)

mRNA Protein Name
NM_017347.3 NP_059043.2 mitogen-activated protein kinase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15027896 RGD
enables MAP kinase activity IDA
IDA: Inferred from direct assay
7889942 RGD
enables MAP kinase activity IMP
IMP: Inferred from mutant phenotype
16955078 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15781236 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
20455999 RGD
Biological Process GO Annotation Evidence References Source
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
17310240 RGD
involved in arachidonate metabolic process IEP
IEP: Inferred from expression pattern
15027896 RGD
involved in cellular response to toxic substance IDA
IDA: Inferred from direct assay
12487375 RGD
involved in decidualization IDA
IDA: Inferred from direct assay
21248290 RGD
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
12072413 RGD
involved in peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
16955078 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
15027896 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15027896 RGD
involved in protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
7889942 RGD
involved in response to toxic substance IDA
IDA: Inferred from direct assay
17651772 RGD
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
24567387 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
24567387 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
7889942 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
24567387 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15781236 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk3 Protein Structure

STKc_ERK1_2_like

STKc_ERK1_2_like: cd07849 (36 - 396)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 3

  • MAP kinase 1

  • MAP kinase 3

  • MAPK 1

  • MAPK 3

  • extracellular signal-regulated kinase 1

  • insulin-stimulated MAP2 kinase

  • microtubule-associated protein 2 kinase

  • mitogen-activated 3

  • mitogen-activated protein kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70844 MAP2K2 Recombinant Human Active Protein Kinase / Unkown
HY-RS08113 MAPK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08114 Mapk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08115 Mapk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk3 NCBI NCBI:5595