Sirt6 - sirtuin 6 Gene

Also Known as Sir2l6; mSIRT6; 2810449N18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50721

About Sirt6

Chromosome 10: 81,457,619-81,463,631 reverse strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 54 phenotypes. Ubiquitous expression in thymus adult (RPKM 15.8), ovary adult (RPKM 15.8) and 28 other tissues.

Summary

Enables several functions, including NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); and transcription corepressor activity. Involved in several processes, including cellular protein modification process; negative regulation of nucleobase-containing compound metabolic process; and positive regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (Sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

Sirt6 Products (4)

mRNA Protein Name
NM_181586.4 NP_853617.1 NAD-dependent protein deacylase sirtuin-6 isoform 1
NM_001378944.1 NP_001365873.1 NAD-dependent protein deacylase sirtuin-6 isoform 1
NM_001163430.2 NP_001156902.1 NAD-dependent protein deacylase sirtuin-6 isoform 2
NM_001378945.1 NP_001365874.1 NAD-dependent protein deacylase sirtuin-6 isoform 2

Sirt6 Protein Structure

SIRT7

SIRT7: cd01410 (44 - 256)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacylase sirtuin-6

NAD-dependent protein deacetylase sirtuin-6

  • NAD-dependent deacetylase sirtuin-6

  • SIR2-like protein 6

  • protein mono-ADP-ribosyltransferase sirtuin-6

  • regulatory protein SIR2 homolog 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107454 OSS_128167 Inhibitor 98.92% Unkown
HY-115453 UBCS039 Activator 98.88% Unkown
HY-N0010 Geniposidic acid Agonist 98.87% Unkown
HY-119376 MDL-800 Activator 99.11% Unkown
HY-148712 SIRT6 activator 12q Activator 99.83% Unkown
HY-103721 SIRT6-IN-2 Inhibitor 99.92% Unkown
HY-156757 MDL-811 Activator 99.68% Unkown
HY-16605 SIRT6-IN-6 Inhibitor 98.59% Unkown
HY-156027 SIRT6-IN-3 Inhibitor 98.19% Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor 98.37% Unkown
HY-P3364A Ac-QPKK(Ac)-AMC acetate Substrate 99.38% Unkown
HY-153104 CrBKA 98.46% Unkown
HY-178990 SIRT6-IN-5 Inhibitor / Unkown
HY-170402 SIRT6-IN-4 Inhibitor / Unkown
HY-177878 IMU-856 Modulator / Unkown
HY-182061 SIRT6 activator 3 Activator / Unkown
HY-169159 SIRT6 activator 2 Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt6 NCBI NCBI:51548