Mapk6 - mitogen-activated protein kinase 6 Gene

Also Known as Erk3; Mapk4; Prkm4; Prkm6; Mapk63; 2610021I23Rik; D130053K17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50772

Summary

Enables MAP kinase activity; protein heterodimerization activity; and protein kinase binding activity. Involved in protein phosphorylation. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin Cytoskeleton. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK6 (mitogen-activated protein kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Mapk6 Products (2)

mRNA Protein Name
NM_015806.5 NP_056621.4 mitogen-activated protein kinase 6
NM_027418.2 NP_081694.1 mitogen-activated protein kinase 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MAP kinase activity IDA
IDA: Inferred from direct assay
15577943 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15538386 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
16973613 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
22508986 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
15577943 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of dendritic spine development IGI
IGI: Inferred from genetic interaction
22508986 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15577943 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15538386 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15577943 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
22508986 MGI
located in septin cytoskeleton IDA
IDA: Inferred from direct assay
22508986 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitogen-activated protein kinase 6

  • Erk-3 related

  • MAP kinase 6

  • extracellular signal-regulated kinase 3

  • mitogen activated protein kinase 4

  • protein kinase, mitogen activated kinase 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1568 Flagelin 22 Agonist 97.61% Unkown
HY-P1568A Flagelin 22 TFA Agonist 99.92% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-RS08117 MAPK6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19216 Mapk6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25705 Mapk6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk6 NCBI NCBI:5597