HP1BP3 - heterochromatin protein 1 binding protein 3 Gene

Also Known as HP1BP74; HP1-BP74

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50809

About HP1BP3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,740,266-20,787,307 (from NCBI)

This gene has 14 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in thyroid (RPKM 36.6), endometrium (RPKM 35.9) and 25 other tissues.

Summary

Enables DNA binding activity and nucleosome binding activity. Involved in several processes, including cellular response to hypoxia; heterochromatin organization; and regulation of nucleus size. Located in chromosome and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

HP1BP3 Products (16)

mRNA Protein Name
NM_001372052.1 NP_001358981.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376787.1 NP_001363716.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376788.1 NP_001363717.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376789.1 NP_001363718.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376790.1 NP_001363719.1 heterochromatin protein 1-binding protein 3 isoform 1
NM_001376791.1 NP_001363720.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376792.1 NP_001363721.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376793.1 NP_001363722.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376794.1 NP_001363723.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001376795.1 NP_001363724.1 heterochromatin protein 1-binding protein 3 isoform 3
NM_001376796.1 NP_001363725.1 heterochromatin protein 1-binding protein 3 isoform 3
NM_001376797.1 NP_001363726.1 heterochromatin protein 1-binding protein 3 isoform 4
NM_001399820.1 NP_001386749.1 heterochromatin protein 1-binding protein 3 isoform 5
NM_001399821.1 NP_001386750.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_001399823.1 NP_001386752.1 heterochromatin protein 1-binding protein 3 isoform 2
NM_016287.5 NP_057371.2 heterochromatin protein 1-binding protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
20042602 GOA
enables nucleosome binding IDA
IDA: Inferred from direct assay
20042602 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20042602 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
25100860 GOA
involved in heterochromatin organization IMP
IMP: Inferred from mutant phenotype
24830416 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24830416 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
24830416 GOA
involved in regulation of nucleus size IMP
IMP: Inferred from mutant phenotype
24830416 GOA
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
20042602 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24830416 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HP1BP3 Protein Structure

Linker_histone

Linker_histone: linker histone H1 and H5 family (159 - 230)

Linker_histone

Linker_histone: linker histone H1 and H5 family (267 - 330)

Linker_histone

Linker_histone: linker histone H1 and H5 family (346 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 553 a.a.
Protein Preferred Names Protein Names

heterochromatin protein 1-binding protein 3

HP1BP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HP1BP3 Q5SSJ5 H2AC4 Homo sapiens P04908
Crosslink
30021884
Intra
HP1BP3 Q5SSJ5 H2AC4 Homo sapiens P04908
Anti Tag CoIP
33961781
Intra
HP1BP3 Q5SSJ5 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
HP1BP3 Q5SSJ5 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Methylmalonic Aciduria, Cblb Type

  • Methylmalonic Aciduria Cblb Type

  • Methylmalonic Acidemia Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

  • Methylmalonic Acidemia, Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

  • Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

  • Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

  • Methylmalonic Aciduria Type Cblb

  • MMAB

  • Methylmalonic Aciduria Type B

  • Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

  • Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

  • Aciduria, Methylmalonic, Cblb Type

  • Methylmalonic Acidemia

  • Methylmalonic Aciduria
Postpartum Depression

  • Maternity Blues

  • Postnatal Depression

  • Depression, Postpartum

  • Post-Partum Depression

  • Depression Postpartum
Endogenous Depression

  • Clinical Depression

  • Unipolar Depression

  • Depressive Disorder
Cataract 34, Multiple Types

  • Cataract, Autosomal Recessive Congenital 3

  • Cataract 34 Multiple Types

  • CTRCT34

  • Catc3

  • Cataract 34, Multiple Types, With Or Without Microcornea

  • Autosomal Recessive Congenital Cataract 3

  • Cataract 34 Multiple Types With Or Without Microcornea

  • Cataract, Multiple Types, Type 34
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06332 HP1BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HP1BP3 VGNC VGNC:62835
Bos taurus HP1BP3 VGNC VGNC:29935
Mus musculus HP1BP3 MGD MGI:109369
Rattus norvegicus HP1BP3 RGD RGD:735099
Macaca mulatta HP1BP3 VGNC VGNC:73440
Canis familiaris HP1BP3 VGNC VGNC:41767
Others HP1BP3 NCBI