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CLEC1A - C-type lectin domain family 1 member A Gene

Also Known as CLEC1; CLEC-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51267

About CLEC1A

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,069,554-10,098,985 (from NCBI)

This gene has 5 transcripts (splice variants), 370 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 18.1), lung (RPKM 3.8) and 10 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CLEC1A Products (5)

mRNA	Protein	Name
NM_001297748.2	NP_001284677.1	C-type lectin domain family 1 member A isoform b
NM_001297749.2	NP_001284678.1	C-type lectin domain family 1 member A isoform c
NM_001297750.2	NP_001284679.1	C-type lectin domain family 1 member A isoform d
NM_001297751.2	NP_001284680.1	C-type lectin domain family 1 member A isoform d
NM_016511.4	NP_057595.2	C-type lectin domain family 1 member A isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC1A Protein Structure

Lectin_C

0
100
200
280 a.a.

Protein Preferred Names	Protein Names
C-type lectin domain family 1 member A	C-type lectin-like receptor-1

CLEC1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLEC1A	Q8NC01	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	CLEC1A	Q8NC01	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	CLEC1A	Q8NC01	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	CLEC12A	Homo sapiens	Q5QGZ9	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	CLEC12A	Homo sapiens	Q5QGZ9	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	CLEC1A	Q8NC01	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	RNF19B	Homo sapiens	Q6ZMZ0	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	CLEC1A	Q8NC01	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	LRRC4C	Homo sapiens	Q9HCJ2	Validated Y2H	32296183
Intra	CLEC1A	Q8NC01	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	LRRC4C	Homo sapiens	Q9HCJ2	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	MRPS18B	Homo sapiens	Q9Y676	Y2H Array	32296183
Intra	CLEC1A	Q8NC01	MRPS18B	Homo sapiens	Q9Y676	Y2H Prey Pooling	32296183
Intra	CLEC1A	Q8NC01	MRPS18B	Homo sapiens	Q9Y676	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLEC1A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75338	CLEC-1/CLEC1A Protein, Human (HEK293, Fc)	Q8NC01/NP_057595.2 (Q77-D280)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Glioblastoma Proneural Subtype
White Piedra	Tinea Blanca Trichosporosis Nodosa
Autoimmune Atherosclerosis
Subcutaneous Mycosis	Subcutaneous Fungal Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02785	CLEC1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19055	Clec1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25545	Clec1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLEC1A	VGNC	VGNC:71335
Bos taurus	CLEC1A	VGNC	VGNC:27427
Mus musculus	CLEC1A	MGD	MGI:2444151
Rattus norvegicus	CLEC1A	RGD	RGD:1566110
Felis catus	CLEC1A	VGNC	VGNC:83534
Others	CLEC1A	NCBI