PCF11 - PCF11 cleavage and polyadenylation factor subunit Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51585

About PCF11

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:83,157,131-83,187,451 (from NCBI)

This gene has 8 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in lymph node (RPKM 13.1), spleen (RPKM 12.7) and 25 other tissues.

Summary

The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]

PCF11 Products (4)

mRNA Protein Name
NM_001346413.3 NP_001333342.1 pre-mRNA cleavage complex 2 protein Pcf11 isoform 1
NM_001346414.2 NP_001333343.1 pre-mRNA cleavage complex 2 protein Pcf11 isoform 2
NM_001346415.2 NP_001333344.1 pre-mRNA cleavage complex 2 protein Pcf11 isoform 4
NM_015885.4 NP_056969.2 pre-mRNA cleavage complex 2 protein Pcf11 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II complex binding IDA
IDA: Inferred from direct assay
29196535 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Biological Process GO Annotation Evidence References Source
involved in termination of RNA polymerase II transcription IDA
IDA: Inferred from direct assay
29196535 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
29196535 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCF11 Protein Structure

CTD_bind

CTD_bind: RNA polymerase II-binding domain. (70 - 124)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1555 a.a.
Protein Preferred Names Protein Names

pre-mRNA cleavage complex 2 protein Pcf11

  • PCF11, cleavage and polyadenylation factor subunit, homolog

PCF11 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PCF11 O94913 CLP1 Homo sapiens Q92989
Pull Down
35177536
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149452 SJ1008066 Inhibitor / Unkown
HY-RS10144 PCF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCF11 RGD RGD:1563397
Bos taurus PCF11 VGNC VGNC:32625
Canis familiaris PCF11 VGNC VGNC:44299
Mus musculus PCF11 MGD MGI:1919579
Macaca mulatta PCF11 VGNC VGNC:75701
Felis catus PCF11 VGNC VGNC:64065
Others PCF11 NCBI