2. Gene
  3. PCF11 - PCF11 cleavage and polyadenylation factor subunit Gene

PCF11 - PCF11 cleavage and polyadenylation factor subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 51585 | Gene type: protein coding

About PCF11

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:83,157,131-83,187,451 (from NCBI)

This gene has 8 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in lymph node (RPKM 13.1), spleen (RPKM 12.7) and 25 other tissues.

Summary

The protein encoded by this gene binds to CLP1 to form pre-mRNA cleavage factor IIm. The encoded protein is necessary for efficient Pol II transcription termination and may be involved in degradation of the 3' product of polyA site cleavage. [provided by RefSeq, Oct 2016]

PCF11 Products(4)

mRNA Protein Name
NM_001346413.3 NP_001333342.1 pre-mRNA cleavage complex 2 protein Pcf11 isoform 1
NM_001346414.2 NP_001333343.1 pre-mRNA cleavage complex 2 protein Pcf11 isoform 2
NM_001346415.2 NP_001333344.1 pre-mRNA cleavage complex 2 protein Pcf11 isoform 4
NM_015885.4 NP_056969.2 pre-mRNA cleavage complex 2 protein Pcf11 isoform 3

PCF11 Protein Structure

CTD_bind

CTD_bind: RNA polymerase II-binding domain. (70 - 124)

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  • 1555 a.a.
Protein Preferred Names Protein Names

pre-mRNA cleavage complex 2 protein Pcf11

PCF11, cleavage and polyadenylation factor subunit, homolog

Related Diseases

Diseases Alias
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10144 PCF11 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCF11 RGD RGD:1563397
Bos taurus PCF11 VGNC VGNC:32625
Canis familiaris PCF11 VGNC VGNC:44299
Mus musculus PCF11 MGD MGI:1919579
Macaca mulatta PCF11 VGNC VGNC:75701
Felis catus PCF11 VGNC VGNC:64065