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GNG13 - G protein subunit gamma 13 Gene

Also Known as HG3J; h2-35; G(gamma)13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51764

About GNG13

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:798,041-800,734 (from NCBI)

This gene has 1 transcript (splice variant) and 191 orthologues. Low expression observed in reference dataset.

Summary

Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

GNG13 Products (1)

mRNA	Protein	Name
NM_016541.3	NP_057625.1	guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein beta-subunit binding	IPI IPI: Inferred from physical interaction	12606627	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG13 Protein Structure

G-gamma

0
67 a.a.

Protein Preferred Names	Protein Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	G gamma subunit, clone:h2-35

GNG13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GNG13	Q9P2W3	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	GNG13	Q9P2W3	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	GNG13	Q9P2W3	BEX5	Homo sapiens	Q5H9J7	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	BEX5	Homo sapiens	Q5H9J7	Y2H Array	32296183
Intra	GNG13	Q9P2W3	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	GNG13	Q9P2W3	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	KRT37	Homo sapiens	O76014	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	KRT37	Homo sapiens	O76014	Y2H Array	32296183
Intra	GNG13	Q9P2W3	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	GNG13	Q9P2W3	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	GNG13	Q9P2W3	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	GNG13	Q9P2W3	UQCC2	Homo sapiens	Q9BRT2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	UQCC2	Homo sapiens	Q9BRT2	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	GNG13	Q9P2W3	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	GNG13	Q9P2W3	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	GNG13	Q9P2W3	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	RSPO4	Homo sapiens	Q2I0M5	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	RSPO4	Homo sapiens	Q2I0M5	Y2H Array	32296183
Intra	GNG13	Q9P2W3	HOXA10	Homo sapiens	P31260-2	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	HOXA10	Homo sapiens	P31260-2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	GNG13	Q9P2W3	VPS16	Homo sapiens	Q6GMQ7	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	FTO	Homo sapiens	Q9C0B1-2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	FTO	Homo sapiens	Q9C0B1-2	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	HAUS3	Homo sapiens	Q68CZ6	Y2H Array	32296183
Intra	GNG13	Q9P2W3	HAUS3	Homo sapiens	Q68CZ6	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	GNG13	Q9P2W3	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	GNG13	Q9P2W3	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	GNG13	Q9P2W3	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	GNG13	Q9P2W3	PLSCR2	Homo sapiens	Q9NRY7	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	PLSCR2	Homo sapiens	Q9NRY7	Y2H Array	32296183
Intra	GNG13	Q9P2W3	RASSF10	Homo sapiens	A6NK89	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	RASSF10	Homo sapiens	A6NK89	Y2H Array	32296183
Intra	GNG13	Q9P2W3	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	GNG13	Q9P2W3	WASHC3	Homo sapiens	Q9Y3C0	Y2H Array	32296183
Intra	GNG13	Q9P2W3	WASHC3	Homo sapiens	Q9Y3C0	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	32296183
Intra	GNG13	Q9P2W3	ABI3	Homo sapiens	Q9P2A4	Y2H Array	32296183
Intra	GNG13	Q9P2W3	TEAD2	Homo sapiens	Q15562-2	Y2H Array	32296183
Intra	GNG13	Q9P2W3	TEAD2	Homo sapiens	Q15562-2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GNG13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76368	GNG13 Protein, Human (His)	Q9P2W3 (M1-C64)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05555	GNG13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19201	Gng13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25689	Gng13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GNG13	VGNC	VGNC:41319
Macaca mulatta	GNG13	VGNC	VGNC:72940
Felis catus	GNG13	VGNC	VGNC:62623
Rattus norvegicus	GNG13	RGD	RGD:1593806
Bos taurus	GNG13	VGNC	VGNC:29464
Mus musculus	GNG13	MGD	MGI:1925616
Others	GNG13	NCBI