2. Gene
  3. Pbk - PDZ binding kinase Gene

Pbk - PDZ binding kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TOPK; D14Ertd732e; 2810434B10Rik

Gene ID: 52033 | Gene type: protein coding

About Pbk

Chromosome 14: 66,043,286-66,055,271 forward strand.GRCm39:CM001007.3

This gene has 3 transcripts (splice variants), 208 orthologues and is associated with 8 phenotypes. Biased expression in CNS E11.5 (RPKM 25.9), liver E14 (RPKM 15.6) and 1 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to UV; negative regulation of cellular protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pbk Products(1)

mRNA Protein Name
NM_023209.2 NP_075698.1 lymphokine-activated killer T-cell-originated protein kinase

Pbk Protein Structure

PKc_TOPK

PKc_TOPK: cd14001 (30 - 317)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

lymphokine-activated killer T-cell-originated protein kinase

MAPKK-like protein kinase

T-LAK cell-originated protein kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120346 PBK-IN-9 Inhibitor / Unkown
HY-RS10101 PBK Human Pre-designed siRNA Set A / Unkown
HY-RS10102 Pbk Mouse Pre-designed siRNA Set A / Unkown
HY-RS10103 Pbk Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pbk NCBI NCBI:55872