Pbk - PDZ binding kinase Gene

Also Known as TOPK; D14Ertd732e; 2810434B10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 52033

About Pbk

Chromosome 14: 66,043,286-66,055,271 forward strand.GRCm39:CM001007.3

This gene has 3 transcripts (splice variants), 208 orthologues and is associated with 8 phenotypes. Biased expression in CNS E11.5 (RPKM 25.9), liver E14 (RPKM 15.6) and 1 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to UV; negative regulation of cellular protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pbk Products (1)

mRNA Protein Name
NM_023209.2 NP_075698.1 lymphokine-activated killer T-cell-originated protein kinase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
21715333 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to UV IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of or within negative regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21715333 MGI
acts upstream of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
21715333 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pbk Protein Structure

PKc_TOPK

PKc_TOPK: cd14001 (30 - 317)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

lymphokine-activated killer T-cell-originated protein kinase

  • MAPKK-like protein kinase

  • T-LAK cell-originated protein kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120346 PBK-IN-9 Inhibitor 98.45% Unkown
HY-RS10101 PBK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10102 Pbk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10103 Pbk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pbk NCBI NCBI:55872