PBK - PDZ binding kinase Gene

Also Known as SPK; CT84; TOPK; HEL164; Nori-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55872

About PBK

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:27,809,624-27,837,817 (from NCBI)

This gene has 4 transcripts (splice variants) and 208 orthologues. Biased expression in testis (RPKM 35.2), lymph node (RPKM 5.8) and 8 other tissues.

Summary

This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PBK Products (3)

mRNA Protein Name
NM_001278945.2 NP_001265874.1 lymphokine-activated killer T-cell-originated protein kinase isoform 2
NM_018492.4 NP_060962.2 lymphokine-activated killer T-cell-originated protein kinase isoform 1
NM_001363040.2 NP_001349969.1 lymphokine-activated killer T-cell-originated protein kinase isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10779557 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
25575812 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PBK Protein Structure

Pkinase

Pkinase: Protein kinase domain (35 - 316)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

lymphokine-activated killer T-cell-originated protein kinase

  • MAPKK-like protein kinase

  • T-LAK cell-originated protein kinase

  • cancer/testis antigen 84

  • epididymis luminal protein 164

  • serine/threonine protein kinase

  • spermatogenesis-related protein kinase

PBK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PBK Q96KB5 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
Intra
PBK Q96KB5 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
Intra
PBK Q96KB5 MCRS1 Homo sapiens Q96EZ8
Y2H Array
32296183
Intra
PBK Q96KB5 MCRS1 Homo sapiens Q96EZ8
Y2H Prey Pooling
32296183
Intra
PBK Q96KB5 TP53 Homo sapiens P04637
Y2H
17482142
Intra
PBK Q96KB5 TP53 Homo sapiens P04637
Anti Bait CoIP
17482142
Intra
PBK Q96KB5 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PBK Q96KB5 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PBK Proteins

Cat. No. Product Name Accession Purity
HY-P77122 PBK/TOPK Protein, Human (sf9, His) Q96KB5-1 (M1-V322) ≥ 95%, as determined by Bis-Tris PAGE.

PBK Antibodies

Cat. No. Product Name Application Reactivity
HY-P81511 PBK Antibody (YA1256) IHC-P Human
HY-P81511A PBK Antibody (YA1256)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Bullous Keratopathy

  • Bk - [Bullous Keratopathy]
Perforated Corneal Ulcer
Hematologic Cancer

  • Hematologic Neoplasm

  • Hematologic Malignancies

  • Hematologic Neoplasms

  • Blood Cancer

  • Hematologic Malignancy

  • Hematological Tumors

  • Hematopoietic And Lymphoid System Tumor

  • Hematopoietic Cancer

  • Hematopoietic Neoplasm

  • Hematopoietic Tumors

  • Malignant Hematopoietic Neoplasm

  • Liquid Tumor

  • Hematopoietic Neoplasms
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Corneal Edema

  • Corneal Oedema

  • Infiltrate Of Cornea
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120346 PBK-IN-9 Inhibitor 98.45% Unkown
HY-RS10101 PBK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10102 Pbk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10103 Pbk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PBK VGNC VGNC:75643
Mus musculus PBK MGD MGI:1289156
Bos taurus PBK VGNC VGNC:59199
Felis catus PBK VGNC VGNC:64054
Rattus norvegicus PBK RGD RGD:1309565
Others PBK NCBI