Rnf5 - ring finger protein 5 Gene

Also Known as NG2; 2410131O05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 54197

Summary

Predicted to enable identical protein binding activity; ubiquitin protein Ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Acts upstream of or within several processes, including negative regulation of autophagy; protein destabilization; and regulation of autophagosome assembly. Located in membrane. Is expressed in dorsal root ganglion; limb; neural tube; testis; and urinary system. Orthologous to human RNF5 (ring finger protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Rnf5 Products (1)

mRNA Protein Name
NM_019403.3 NP_062276.1 E3 ubiquitin-protein ligase RNF5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23093945 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23093945 MGI
acts upstream of or within protein destabilization IDA
IDA: Inferred from direct assay
23093945 MGI
acts upstream of or within protein ubiquitination IDA
IDA: Inferred from direct assay
23093945 MGI
acts upstream of or within regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
23093945 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
23093945 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
23093945 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF5

  • RING-type E3 ubiquitin transferase RNF5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123967 RNF5 inhibitor inh-02 99.91% Unkown
HY-170515 RNF5 agonist 1 Agonist 99.05% Unkown
HY-167673 RNF5-IN-1 Degrader 98.52% Unkown
HY-170515A (E),(Z)-RNF5 agonist 1 / Unkown
HY-RS12094 RNF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17414 Rnf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23868 Rnf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnf5 NCBI NCBI:6048