ERRFI1 - ERBB receptor feedback inhibitor 1 Gene

Also Known as MIG6; RALT; MIG-6; GENE-33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54206

About ERRFI1

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:8,011,727-8,026,309 (from NCBI)

This gene has 5 transcripts (splice variants) and 259 orthologues. Broad expression in liver (RPKM 123.7), gall bladder (RPKM 60.1) and 20 other tissues.

Summary

ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]

ERRFI1 Products (1)

mRNA Protein Name
NM_018948.4 NP_061821.1 ERBB receptor feedback inhibitor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15778465 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18046415 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epidermal growth factor-activated receptor activity IDA
IDA: Inferred from direct assay
18046415 GOA
involved in negative regulation of protein autophosphorylation IDA
IDA: Inferred from direct assay
18046415 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERRFI1 Protein Structure

GTPase_binding

GTPase_binding: GTPase binding (4 - 68)

Inhibitor_Mig-6

Inhibitor_Mig-6: EGFR receptor inhibitor Mig-6 (315 - 371)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

ERBB receptor feedback inhibitor 1

  • mitogen-inducible gene 6 protein

ERRFI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ERRFI1 Q9UJM3 FYN Homo sapiens P06241-3
Y2H Prey Pooling
32296183
Intra
ERRFI1 Q9UJM3 FYN Homo sapiens P06241-3
Y2H Array
32296183
Intra
ERRFI1 Q9UJM3 EGFR Homo sapiens P00533
X-Ray Diffraction
18046415
Intra
ERRFI1 Q9UJM3 EGFR Homo sapiens P00533
Fluorescence Spectr
18046415
Intra
ERRFI1 Q9UJM3 EGFR Homo sapiens P00533
TAP
24189400
Intra
ERRFI1 Q9UJM3 GRB2 Homo sapiens P62993
Y2H Prey Pooling
32296183
Intra
ERRFI1 Q9UJM3 GRB2 Homo sapiens P62993
TAP
24189400
Intra
ERRFI1 Q9UJM3 GRB2 Homo sapiens P62993
Y2H Array
32296183
Intra
ERRFI1 Q9UJM3 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra
ERRFI1 Q9UJM3 GRB2 Homo sapiens P62993
Anti Tag CoIP
33961781
Intra
ERRFI1 Q9UJM3 SFN Homo sapiens P31947
Anti Tag CoIP
15778465
Intra
ERRFI1 Q9UJM3 ERBB2 Homo sapiens P04626
Y2H Array
25640309
Intra
ERRFI1 Q9UJM3 ERBB2 Homo sapiens P04626
TAP
24189400
Intra
ERRFI1 Q9UJM3 CHEK1 Homo sapiens O14757
Enzymatic Study
22505024
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04516 ERRFI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19775 Errfi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26272 Errfi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ERRFI1 VGNC VGNC:28598
Macaca mulatta ERRFI1 VGNC VGNC:99913
Rattus norvegicus ERRFI1 RGD RGD:1307599
Mus musculus ERRFI1 MGD MGI:1921405
Canis familiaris ERRFI1 VGNC VGNC:40469
Felis catus ERRFI1 VGNC VGNC:61958
Others ERRFI1 NCBI