GNG2 - G protein subunit gamma 2 Gene

Also Known as HG3F1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54331

About GNG2

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,826,174-51,969,795 (from NCBI)

This gene has 16 transcripts (splice variants), 188 orthologues and 11 paralogues. Broad expression in brain (RPKM 43.3), spleen (RPKM 22.6) and 23 other tissues.

Summary

This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]

GNG2 Products (7)

mRNA Protein Name
NM_001243773.2 NP_001230702.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor
NM_001243774.2 NP_001230703.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor
NM_001389707.1 NP_001376636.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor
NM_001389708.1 NP_001376637.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor
NM_001389709.1 NP_001376638.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor
NM_001389710.1 NP_001376639.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor
NM_053064.5 NP_444292.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein beta-subunit binding IPI
IPI: Inferred from physical interaction
12606627 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23739333 GOA
Cellular Component GO Annotation Evidence References Source
part of heterotrimeric G-protein complex IDA
IDA: Inferred from direct assay
29925951 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG2 Protein Structure

G-gamma

G-gamma: GGL domain (7 - 71)

  • 0
  • 71 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

  • g gamma-I

GNG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNG2 P59768 GNB1 Homo sapiens P62873
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21352 Gng2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05556 GNG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27871 Gng2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GNG2 RGD RGD:69268
Mus musculus GNG2 MGD MGI:102705
Canis familiaris GNG2 VGNC VGNC:53494
Bos taurus GNG2 VGNC VGNC:29465
Others GNG2 NCBI